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Effects of Etanercept against Transient Cerebral Ischemia in Diabetic Rats
Joint Authors
Iwata, Naohiro
Takayama, Hiroko
Xuan, Meiyan
Kamiuchi, Shinya
Matsuzaki, Hirokazu
Okazaki, Mari
Hibino, Yasuhide
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetes mellitus is known to exacerbate acute cerebral ischemic injury.
Previous studies have demonstrated that infarction volumes caused by transient cerebral ischemia were greater in diabetic rats than in nondiabetic rats.
Tumor necrosis factor-α (TNF-α) is a proinflammatory protein produced in the brain in response to cerebral ischemia that promotes apoptosis.
Etanercept (ETN), a recombinant TNF receptor (p75)-Fc fusion protein, competitively inhibits TNF-α.
Therefore, we evaluated the neuroprotective effects of chronic or acute treatment with ETN on cerebral injury caused by middle cerebral artery occlusion/reperfusion (MCAO/Re) in rats with streptozotocin-induced diabetes.
Furthermore, we evaluated the effects of ETN against the apoptosis and myeloperoxidase activity.
Single administration of ETN before MCAO significantly suppressed exacerbation of cerebral damage in nondiabetic rats, as assessed by infarct volume.
In contrast, the diabetic state markedly aggravated MCAO/Re-induced cerebral damage despite ETN treatment within 24 h before MCAO.
However, the damage was improved by repeated administration of ETN at 900 μg/kg/daily in rats in an induced diabetic state.
These results suggested that repeated administration of ETN can prevent exacerbation of cerebral ischemic injury in the diabetic state and is mainly attributed to anti-inflammatory effects.
American Psychological Association (APA)
Iwata, Naohiro& Takayama, Hiroko& Xuan, Meiyan& Kamiuchi, Shinya& Matsuzaki, Hirokazu& Okazaki, Mari…[et al.]. 2015. Effects of Etanercept against Transient Cerebral Ischemia in Diabetic Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054557
Modern Language Association (MLA)
Iwata, Naohiro…[et al.]. Effects of Etanercept against Transient Cerebral Ischemia in Diabetic Rats. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054557
American Medical Association (AMA)
Iwata, Naohiro& Takayama, Hiroko& Xuan, Meiyan& Kamiuchi, Shinya& Matsuzaki, Hirokazu& Okazaki, Mari…[et al.]. Effects of Etanercept against Transient Cerebral Ischemia in Diabetic Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054557