![](/images/graphics-bg.png)
Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review
Joint Authors
Torres-Bugarín, Olivia
Macriz Romero, Nicole
Ramos Ibarra, María Luisa
Flores-García, Aurelio
Valdez Aburto, Penélope
Zavala-Cerna, María Guadalupe
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Autoimmune diseases (AD) are classified into organ-specific, systemic, and mixed; all forms of AD share a high risk for cancer development.
In AD a destructive immune response induced by autoreactive lymphocytes is started and continues with the production of autoantibodies against different targets; furthermore apoptosis failure and loss of balance in oxidative stress as a consequence of local or systemic inflammation are common features seen in AD as well.
Micronucleus (MN) assay can be performed in order to evaluate loss of genetic material in a clear, accurate, fast, simple, and minimally invasive test.
The MN formation in the cytoplasm of cells that have undergone proliferation is a consequence of DNA fragmentation during mitosis and the appearance of small additional nuclei during interphase.
The MN test, widely accepted for in vitro and in vivo genotoxicity research, provides a sensitive marker of genomic damage associated to diverse conditions.
In here, we present a review of our work and other published papers concerning genotoxic effect in AD, identified by means of the MN assay, with the aim of proposing this tool as a possible early biomarker for genotoxic damage, which is a consequence of disease progression.
Additionally this biomarker could be used for follow-up, to asses genome damage associated to therapies.
American Psychological Association (APA)
Torres-Bugarín, Olivia& Macriz Romero, Nicole& Ramos Ibarra, María Luisa& Flores-García, Aurelio& Valdez Aburto, Penélope& Zavala-Cerna, María Guadalupe. 2015. Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054577
Modern Language Association (MLA)
Torres-Bugarín, Olivia…[et al.]. Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054577
American Medical Association (AMA)
Torres-Bugarín, Olivia& Macriz Romero, Nicole& Ramos Ibarra, María Luisa& Flores-García, Aurelio& Valdez Aburto, Penélope& Zavala-Cerna, María Guadalupe. Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054577
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054577