![](/images/graphics-bg.png)
Research Progress on the Role of ABC Transporters in the Drug Resistance Mechanism of Intractable Epilepsy
Joint Authors
Liu, Li-qun
Xiong, Jie
Mao, Ding-an
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The pathogenesis of intractable epilepsy is not fully clear.
In recent years, both animal and clinical trials have shown that the expression of ATP-binding cassette (ABC) transporters is increased in patients with intractable epilepsy; additionally, epileptic seizures can lead to an increase in the number of sites that express ABC transporters.
These findings suggest that ABC transporters play an important role in the drug resistance mechanism of epilepsy.
ABC transporters can perform the funcions of a drug efflux pump, which can reduce the effective drug concentration at epilepsy lesions by reducing the permeability of the blood brain barrier to antiepileptic drugs, thus causing resistance to antiepileptic drugs.
Given the important role of ABC transporters in refractory epilepsy drug resistance, antiepileptic drugs that are not substrates of ABC transporters were used to obtain ABC transporter inhibitors with strong specificity, high safety, and few side effects, making them suitable for long-term use; therefore, these drugs can be used for future clinical treatment of intractable epilepsy.
American Psychological Association (APA)
Xiong, Jie& Mao, Ding-an& Liu, Li-qun. 2015. Research Progress on the Role of ABC Transporters in the Drug Resistance Mechanism of Intractable Epilepsy. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054580
Modern Language Association (MLA)
Xiong, Jie…[et al.]. Research Progress on the Role of ABC Transporters in the Drug Resistance Mechanism of Intractable Epilepsy. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054580
American Medical Association (AMA)
Xiong, Jie& Mao, Ding-an& Liu, Li-qun. Research Progress on the Role of ABC Transporters in the Drug Resistance Mechanism of Intractable Epilepsy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054580