Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks
Joint Authors
Mizuno, Shiro
Ishizaki, Takeshi
Toga, Hirohisa
Sakai, Akio
Isakova, Jainagul
Taalaibekova, Elnura
Baiserkeev, Zamirbek
Kojonazarov, Baktybek
Aldashev, Almaz
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hypoxia-induced and high altitude pulmonary hypertension are a major problem in the mountain areas of the world.
The asymmetric methylarginines (ADMA) inhibit nitric oxide (NO) synthesis by competing with L-arginine, and high levels of plasma ADMA predict adverse outcomes in pulmonary hypertension.
However, little is known about the regulation of the ADMA-NO pathway in animals adapted to high altitudes.
We measured the plasma ADMA concentration, endothelial NO synthase (eNOS), dimethylarginine dimethylaminohydrolases (DDAH) protein expression, and DDAH activities in the lungs from yaks.
Although the yaks are hypoxemic, cardiac function and pulmonary arterial pressures are almost normal, and we found decreased DDAH expression and activity in association with reduced plasma ADMA concentrations.
The eNOS expression was significantly higher in yaks.
These results indicate that augmented endogenous NO activity in yaks through the ADMA-DDAH pathway and eNOS upregulation account for the low pulmonary vascular tone observed in high altitude adapted yaks.
American Psychological Association (APA)
Mizuno, Shiro& Ishizaki, Takeshi& Toga, Hirohisa& Sakai, Akio& Isakova, Jainagul& Taalaibekova, Elnura…[et al.]. 2015. Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054591
Modern Language Association (MLA)
Mizuno, Shiro…[et al.]. Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054591
American Medical Association (AMA)
Mizuno, Shiro& Ishizaki, Takeshi& Toga, Hirohisa& Sakai, Akio& Isakova, Jainagul& Taalaibekova, Elnura…[et al.]. Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054591