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Genome-Wide Methylome Analyses Reveal Novel Epigenetic Regulation Patterns in Schizophrenia and Bipolar Disorder
Joint Authors
Escamilla, Michael A.
Li, Yongsheng
Camarillo, Cynthia
Xu, Juan
Arana, Tania Bedard
Xiao, Yun
Zhao, Zheng
Chen, Hong
Ramirez, Mercedes
Zavala, Juan
Armas, Regina
Mendoza, Ricardo
Ontiveros, Alfonso
Jerez Magaña, Alvaro Antonio
Rubin, Lewis P.
Xu, Chun
Nicolini, Humberto
Li, Xia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-04
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Schizophrenia (SZ) and bipolar disorder (BP) are complex genetic disorders.
Their appearance is also likely informed by as yet only partially described epigenetic contributions.
Using a sequencing-based method for genome-wide analysis, we quantitatively compared the blood DNA methylation landscapes in SZ and BP subjects to control, both in an understudied population, Hispanics along the US-Mexico border.
Remarkably, we identified thousands of differentially methylated regions for SZ and BP preferentially located in promoters 3′-UTRs and 5′-UTRs of genes.
Distinct patterns of aberrant methylation of promoter sequences were located surrounding transcription start sites.
In these instances, aberrant methylation occurred in CpG islands (CGIs) as well as in flanking regions as well as in CGI sparse promoters.
Pathway analysis of genes displaying these distinct aberrant promoter methylation patterns showed enhancement of epigenetic changes in numerous genes previously related to psychiatric disorders and neurodevelopment.
Integration of gene expression data further suggests that in SZ aberrant promoter methylation is significantly associated with altered gene transcription.
In particular, we found significant associations between (1) promoter CGIs hypermethylation with gene repression and (2) CGI 3′-shore hypomethylation with increased gene expression.
Finally, we constructed a specific methylation analysis platform that facilitates viewing and comparing aberrant genome methylation in human neuropsychiatric disorders.
American Psychological Association (APA)
Li, Yongsheng& Camarillo, Cynthia& Xu, Juan& Arana, Tania Bedard& Xiao, Yun& Zhao, Zheng…[et al.]. 2015. Genome-Wide Methylome Analyses Reveal Novel Epigenetic Regulation Patterns in Schizophrenia and Bipolar Disorder. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1054611
Modern Language Association (MLA)
Li, Yongsheng…[et al.]. Genome-Wide Methylome Analyses Reveal Novel Epigenetic Regulation Patterns in Schizophrenia and Bipolar Disorder. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1054611
American Medical Association (AMA)
Li, Yongsheng& Camarillo, Cynthia& Xu, Juan& Arana, Tania Bedard& Xiao, Yun& Zhao, Zheng…[et al.]. Genome-Wide Methylome Analyses Reveal Novel Epigenetic Regulation Patterns in Schizophrenia and Bipolar Disorder. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1054611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054611