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Daycare Attendance, Breastfeeding, and the Development of Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young
Joint Authors
Rewers, Marian
Hall, Katelyn
Norris, Jill M.
Frederiksen, Brittni N.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The hygiene hypothesis attributes the increased incidence of type 1 diabetes (T1D) to a decrease of immune system stimuli from infections.
We evaluated this prospectively in the Diabetes Autoimmunity Study in the Young (DAISY) by examining daycare attendance during the first two years of life (as a proxy for infections) and the risk of T1D.
Methods.
DAISY is a prospective cohort of children at increased T1D risk.
Analyses were limited to 1783 children with complete daycare and breastfeeding data from birth to 2 years of age; 58 children developed T1D.
Daycare was defined as supervised time with at least one other child at least 3 times a week.
Breastfeeding duration was evaluated as a modifier of the effect of daycare.
Cox proportional hazards regression was used for analyses.
Results.
Attending daycare before the age of 2 years was not associated with T1D risk (HR: 0.89; CI: 0.54–1.47) after adjusting for HLA, first degree relative with T1D, ethnicity, and breastfeeding duration.
Breastfeeding duration modified this association, where daycare attendance was associated with increased T1D risk in nonbreastfed children and a decreasing T1D risk with increasing breastfeeding duration (interaction P value = 0.02).
Conclusions.
These preliminary data suggest breastfeeding may modify the effect of daycare on T1D risk.
American Psychological Association (APA)
Hall, Katelyn& Frederiksen, Brittni N.& Rewers, Marian& Norris, Jill M.. 2015. Daycare Attendance, Breastfeeding, and the Development of Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1054619
Modern Language Association (MLA)
Hall, Katelyn…[et al.]. Daycare Attendance, Breastfeeding, and the Development of Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1054619
American Medical Association (AMA)
Hall, Katelyn& Frederiksen, Brittni N.& Rewers, Marian& Norris, Jill M.. Daycare Attendance, Breastfeeding, and the Development of Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1054619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054619