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Altered Spontaneous Brain Activity in Schizophrenia: A Meta-Analysis and a Large-Sample Study
Joint Authors
Xu, Yongjie
Zhuo, Chuanjun
Zhu, Jiajia
Qin, Wen
Yu, Chunshui
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Altered spontaneous brain activity as measured by ALFF, fALFF, and ReHo has been reported in schizophrenia, but no consensus has been reached on alternations of these indexes in the disorder.
We aimed to clarify the regional alterations in ALFF, fALFF, and ReHo in schizophrenia using a meta-analysis and a large-sample validation.
A meta-analysis of activation likelihood estimation was conducted based on the abnormal foci of ten studies.
A large sample of 86 schizophrenia patients and 89 healthy controls was compared to verify the results of the meta-analysis.
Meta-analysis demonstrated that the alternations in ALFF and ReHo had similar distribution in schizophrenia patients.
The foci with decreased ALFF/fALFF and ReHo in schizophrenia were mainly located in the somatosensory cortex, posterior parietal cortex, and occipital cortex; however, foci with increased ALFF/fALFF and ReHo were mainly located in the bilateral striatum, medial temporal cortex, and medial prefrontal cortex.
The large-sample study showed consistent findings with the meta-analysis.
These findings may expound the pathophysiological hypothesis and guide future research.
American Psychological Association (APA)
Xu, Yongjie& Zhuo, Chuanjun& Qin, Wen& Zhu, Jiajia& Yu, Chunshui. 2015. Altered Spontaneous Brain Activity in Schizophrenia: A Meta-Analysis and a Large-Sample Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054622
Modern Language Association (MLA)
Xu, Yongjie…[et al.]. Altered Spontaneous Brain Activity in Schizophrenia: A Meta-Analysis and a Large-Sample Study. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054622
American Medical Association (AMA)
Xu, Yongjie& Zhuo, Chuanjun& Qin, Wen& Zhu, Jiajia& Yu, Chunshui. Altered Spontaneous Brain Activity in Schizophrenia: A Meta-Analysis and a Large-Sample Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054622