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Regulatory Role of Small Nucleolar RNAs in Human Diseases
Joint Authors
Stepanov, Grigoriy A.
Semenov, Dmitry V.
Kuligina, Elena V.
Richter, Vladimir A.
Filippova, Julia A.
Komissarov, Andrey B.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Small nucleolar RNAs (snoRNAs) are appreciable players in gene expression regulation in human cells.
The canonical function of box C/D and box H/ACA snoRNAs is posttranscriptional modification of ribosomal RNAs (rRNAs), namely, 2′-O-methylation and pseudouridylation, respectively.
A series of independent studies demonstrated that snoRNAs, as well as other noncoding RNAs, serve as the source of various short regulatory RNAs.
Some snoRNAs and their fragments can also participate in the regulation of alternative splicing and posttranscriptional modification of mRNA.
Alterations in snoRNA expression in human cells can affect numerous vital cellular processes.
SnoRNA level in human cells, blood serum, and plasma presents a promising target for diagnostics and treatment of human pathologies.
Here we discuss the relation between snoRNAs and oncological, neurodegenerative, and viral diseases and also describe changes in snoRNA level in response to artificial stress and some drugs.
American Psychological Association (APA)
Stepanov, Grigoriy A.& Filippova, Julia A.& Komissarov, Andrey B.& Kuligina, Elena V.& Richter, Vladimir A.& Semenov, Dmitry V.. 2015. Regulatory Role of Small Nucleolar RNAs in Human Diseases. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054630
Modern Language Association (MLA)
Stepanov, Grigoriy A.…[et al.]. Regulatory Role of Small Nucleolar RNAs in Human Diseases. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054630
American Medical Association (AMA)
Stepanov, Grigoriy A.& Filippova, Julia A.& Komissarov, Andrey B.& Kuligina, Elena V.& Richter, Vladimir A.& Semenov, Dmitry V.. Regulatory Role of Small Nucleolar RNAs in Human Diseases. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054630