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Secretome Identifies Tenascin-X as a Potent Marker of Ovarian Cancer
Joint Authors
Kramer, Marianne
Pierredon, Sandra
Ribaux, Pascale
Tille, Jean-Christophe
Petignat, Patrick
Cohen, Marie
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
CA-125 has been a valuable marker for the follow-up of ovarian cancer patients but it is not sensitive enough to be used as diagnostic marker.
We had already used secretomic methods to identify proteins differentially secreted by serous ovarian cancer cells compared to healthy ovarian cells.
Here, we evaluated the secretion of these proteins by ovarian cancer cells during the follow-up of one patient.
Proteins that correlated with CA-125 levels were screened using serum samples from ovarian cancer patients as well as benign and healthy controls.
Tenascin-X secretion was shown to correlate with CA-125 value in the initial case study.
The immunohistochemical detection of increased amount of tenascin-X in ovarian cancer tissues compared to healthy tissues confirms the potent interest in tenascin-X as marker.
We then quantified the tenascin-X level in serum of patients and identified tenascin-X as potent marker for ovarian cancer, showing that secretomic analysis is suitable for the identification of protein biomarkers when combined with protein immunoassay.
Using this method, we determined tenascin-X as a new potent marker for serous ovarian cancer.
American Psychological Association (APA)
Kramer, Marianne& Pierredon, Sandra& Ribaux, Pascale& Tille, Jean-Christophe& Petignat, Patrick& Cohen, Marie. 2015. Secretome Identifies Tenascin-X as a Potent Marker of Ovarian Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054635
Modern Language Association (MLA)
Kramer, Marianne…[et al.]. Secretome Identifies Tenascin-X as a Potent Marker of Ovarian Cancer. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054635
American Medical Association (AMA)
Kramer, Marianne& Pierredon, Sandra& Ribaux, Pascale& Tille, Jean-Christophe& Petignat, Patrick& Cohen, Marie. Secretome Identifies Tenascin-X as a Potent Marker of Ovarian Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054635