Can Exposure to Environmental Chemicals Increase the Risk of Diabetes Type 1 Development?
Joint Authors
Nygaard, Unni Cecilie
Bodin, Johanna
Stene, Lars Christian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-26
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Type 1 diabetes mellitus (T1DM) is an autoimmune disease, where destruction of beta-cells causes insulin deficiency.
The incidence of T1DM has increased in the last decades and cannot entirely be explained by genetic predisposition.
Several environmental factors are suggested to promote T1DM, like early childhood enteroviral infections and nutritional factors, but the evidence is inconclusive.
Prenatal and early life exposure to environmental pollutants like phthalates, bisphenol A, perfluorinated compounds, PCBs, dioxins, toxicants, and air pollutants can have negative effects on the developing immune system, resulting in asthma-like symptoms and increased susceptibility to childhood infections.
In this review the associations between environmental chemical exposure and T1DM development is summarized.
Although information on environmental chemicals as possible triggers for T1DM is sparse, we conclude that it is plausible that environmental chemicals can contribute to T1DM development via impaired pancreatic beta-cell and immune-cell functions and immunomodulation.
Several environmental factors and chemicals could act together to trigger T1DM development in genetically susceptible individuals, possibly via hormonal or epigenetic alterations.
Further observational T1DM cohort studies and animal exposure experiments are encouraged.
American Psychological Association (APA)
Bodin, Johanna& Stene, Lars Christian& Nygaard, Unni Cecilie. 2015. Can Exposure to Environmental Chemicals Increase the Risk of Diabetes Type 1 Development?. BioMed Research International،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1054639
Modern Language Association (MLA)
Bodin, Johanna…[et al.]. Can Exposure to Environmental Chemicals Increase the Risk of Diabetes Type 1 Development?. BioMed Research International No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1054639
American Medical Association (AMA)
Bodin, Johanna& Stene, Lars Christian& Nygaard, Unni Cecilie. Can Exposure to Environmental Chemicals Increase the Risk of Diabetes Type 1 Development?. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1054639
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054639