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Antiproliferative Activity of Flavonoids from Croton sphaerogynus Baill. (Euphorbiaceae)
Joint Authors
Ruiz, Ana Lúcia Tasca Gois
Ferreira, Marcelo J. P.
Santos, Kátia Pereira dos
Motta, Lucimar B.
Santos, Deborah Y. A. C.
Lago, João Henrique G.
Carvalho, João E. de
Furlan, Cláudia M.
Salatino, A.
Salatino, M. L. F.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Croton sphaerogynus is a shrub from the Atlantic Rain Forest in southeastern Brazil.
A lyophilized crude EtOH extract from leaves of C.
sphaerogynus, obtained by maceration at room temperature (seven days), was suspended in methanol and partitioned with hexane.
The purified MeOH phase was fractionated over Sephadex LH-20 yielding five fractions (F1–F5) containing flavonoids, as characterized by HPLC-DAD and HPLC-MS analyses.
The antiproliferative activity of the crude EtOH extract, MeOH and hexane phases, and fractions F1–F5 was evaluated on in vitro cell lines NCI-H460 (nonsmall cell lung), MCF-7 (breast cancer), and U251 (glioma).
The MeOH phase showed activity (mean log GI50 0.54) higher than the hexane phase and EtOH extract (mean log GI50 1.13 and 1.19, resp.).
F1 exhibited activity against NCI-H460 (nonsmall cell lung) (GI50 1.2 μg/mL), which could be accounted for the presence of flavonoids and/or diterpenes.
F4 showed moderate activity (mean log GI50 1.05), while F5 showed weak activity (mean log GI50 1.36).
It is suggested that the antiproliferative activity of the crude EtOH extract and MeOH phase is accounted for a synergistic combination of flavonoids and diterpenes.
American Psychological Association (APA)
Santos, Kátia Pereira dos& Motta, Lucimar B.& Santos, Deborah Y. A. C.& Salatino, M. L. F.& Salatino, A.& Ferreira, Marcelo J. P.…[et al.]. 2015. Antiproliferative Activity of Flavonoids from Croton sphaerogynus Baill. (Euphorbiaceae). BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054649
Modern Language Association (MLA)
Santos, Kátia Pereira dos…[et al.]. Antiproliferative Activity of Flavonoids from Croton sphaerogynus Baill. (Euphorbiaceae). BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054649
American Medical Association (AMA)
Santos, Kátia Pereira dos& Motta, Lucimar B.& Santos, Deborah Y. A. C.& Salatino, M. L. F.& Salatino, A.& Ferreira, Marcelo J. P.…[et al.]. Antiproliferative Activity of Flavonoids from Croton sphaerogynus Baill. (Euphorbiaceae). BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054649
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054649