Inhibitory Effect of a Novel Antirheumatic Drug T-614 on the IL-6-Induced RANKLOPG, IL-17, and MMP-3 Expression in Synovial Fibroblasts from Rheumatoid Arthritis Patients
Joint Authors
Tan, Wenfeng
Sun, Xiaoxuan
Wang, Fang
Wei, Yu
Hua, Minhui
Zhang, Miaojia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
T-614 (also named as iguratimod), a novel antirheumatic drug, could attenuate joint inflammation and articular damage in rheumatoid arthritis (RA) patients, providing a new therapy for RA.
Here, we tested the role T-614 on the IL-6-induced receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG), IL-17, and MMP-3 expression in synovial fibroblasts from rheumatoid arthritis (RASFs) patients.
T-614 decreased RANKL expression and RANKL/OPG ratio in IL-6-induced RASFs.
We confirmed this effect by a decrease of the mRNA and protein RANKL and mRNA RANKL/OPG in RASFs exposed in vitro to T-614 or MTX.
Markedly decreased levels of IL-17, retinoid-related orphan receptor C (RORc), and MMP-3 mRNA expression were also observed in IL-6-induced RASFs in the presence of T-614 or MTX compared with those in its absence.
Furthermore, T-614 blocked expression of p-ERK1/2 protein without affecting ERK1/2 expression, indicating that the way that T-614 regulated RANKL expression might be ERK1/2 pathway.
Our results suggest that T-614 yields a strong improvement in arthritis via exact suppression of RANKL/OPG, IL-17, and MMP-3 expression in RASFs.
American Psychological Association (APA)
Wei, Yu& Sun, Xiaoxuan& Hua, Minhui& Tan, Wenfeng& Wang, Fang& Zhang, Miaojia. 2015. Inhibitory Effect of a Novel Antirheumatic Drug T-614 on the IL-6-Induced RANKLOPG, IL-17, and MMP-3 Expression in Synovial Fibroblasts from Rheumatoid Arthritis Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054656
Modern Language Association (MLA)
Wei, Yu…[et al.]. Inhibitory Effect of a Novel Antirheumatic Drug T-614 on the IL-6-Induced RANKLOPG, IL-17, and MMP-3 Expression in Synovial Fibroblasts from Rheumatoid Arthritis Patients. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054656
American Medical Association (AMA)
Wei, Yu& Sun, Xiaoxuan& Hua, Minhui& Tan, Wenfeng& Wang, Fang& Zhang, Miaojia. Inhibitory Effect of a Novel Antirheumatic Drug T-614 on the IL-6-Induced RANKLOPG, IL-17, and MMP-3 Expression in Synovial Fibroblasts from Rheumatoid Arthritis Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054656