Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats
Joint Authors
Wan Rosli, Wan Ishak
Ng, Sze Han
Mohd Zain, Mohd Shazwan
Zakaria, Fatariah
Wan Ahmad, W. A. N.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Pleurotus sajor-caju (PSC) is an edible oyster mushroom featuring high nutritional values and pharmacological properties.
Objective.
To investigate the hypoglycemic and antidiabetic effects of single and repeated oral administration of PSC aqueous extract in normal and diabetic rats.
Materials and Methods.
A single dose of 500, 750, or 1000 mg/kg of the PSC extract was given to experimental rats to determine the effects on blood glucose (BG) and oral glucose tolerance test (OGTT).
The effective dose (750 mg/kg) of PSC extract was repeatedly administrated daily for 21 days in diabetic rats to examine its antidiabetic effects in terms of BG control, body weight, urine sugar, HbA1c, and several serum profiles.
Results.
The dose of 750 mg/kg showed the most significant BG reduction (23.5%) in normal rats 6 hours after administration in BG study ( p < 0.05 ).
In OGTT study, the same dose produced a maximum BG fall of 41.3% in normal rats and 36.5% in diabetic rats 3 hours after glucose administration.
In 21-day study, treated diabetic rats showed significant improvement in terms of fasting BG, body weight, and urine sugar as compared to control diabetic rats.
Conclusion.
The study evidenced scientifically the beneficial use of PSC as an alternative medicine in diabetes management.
American Psychological Association (APA)
Ng, Sze Han& Mohd Zain, Mohd Shazwan& Zakaria, Fatariah& Wan Rosli, Wan Ishak& Wan Ahmad, W. A. N.. 2015. Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054659
Modern Language Association (MLA)
Ng, Sze Han…[et al.]. Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054659
American Medical Association (AMA)
Ng, Sze Han& Mohd Zain, Mohd Shazwan& Zakaria, Fatariah& Wan Rosli, Wan Ishak& Wan Ahmad, W. A. N.. Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054659