Antioxidant and Anti-Inflammatory Activities of Pomegranate (Punica granatum) on Eimeria papillata-Induced Infection in Mice
Joint Authors
Dkhil, Muhammad A.
Amer, Omar S. O.
Hikal, Wafaa M.
al-Quraishy, Salih
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Coccidiosis is the most prevalent disease causing widespread economic loss, especially in poultry farms.
Here, we investigated the effects of pomegranate peel extract (PPE) on the outcome of coccidiosis caused by Eimeria papillata in mice.
The data showed that mice infected with E.
papillata and treated with PPE revealed a significant decrease in the output of oocysts in their faeces by day 5 p.i.
Infection also induced inflammation and injury of the jejunum.
This was evidenced (i) as increases in reactive oxygen species, (ii), as increased neutrophils and decreased lymphocytes in blood (ii) as increased mRNA levels of inducible nitric oxide synthase (iNOS), Bcl-2 gene, and of the cytokines interferon gamma (IFN-γ), tumour necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), and (iv) as downregulation of mucin gene MUC2 mRNA.
All these infection-induced parameters were significantly altered during PPE treatment.
In particular, PPE counteracted the E.
papillata-induced loss of the total antioxidant capacity.
Our data indicated that PPE treatment significantly attenuated inflammation and injury of the jejunum induced by E.
papillata infections.
American Psychological Association (APA)
Amer, Omar S. O.& Dkhil, Muhammad A.& Hikal, Wafaa M.& al-Quraishy, Salih. 2015. Antioxidant and Anti-Inflammatory Activities of Pomegranate (Punica granatum) on Eimeria papillata-Induced Infection in Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054674
Modern Language Association (MLA)
Amer, Omar S. O.…[et al.]. Antioxidant and Anti-Inflammatory Activities of Pomegranate (Punica granatum) on Eimeria papillata-Induced Infection in Mice. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054674
American Medical Association (AMA)
Amer, Omar S. O.& Dkhil, Muhammad A.& Hikal, Wafaa M.& al-Quraishy, Salih. Antioxidant and Anti-Inflammatory Activities of Pomegranate (Punica granatum) on Eimeria papillata-Induced Infection in Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054674