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Benchtop Technologies for Circulating Tumor Cells Separation Based on Biophysical Properties
Joint Authors
Wan Abas, Wan Abu Bakar
Low, Wan Shi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-21
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Circulating tumor cells (CTCs) are tumor cells that have detached from primary tumor site and are transported via the circulation system.
The importance of CTCs as prognostic biomarker is leveraged when multiple studies found that patient with cutoff of 5 CTCs per 7.5 mL blood has poor survival rate.
Despite its clinical relevance, the isolation and characterization of CTCs can be quite challenging due to their large morphological variability and the rare presence of CTCs within the blood.
Numerous methods have been employed and discussed in the literature for CTCs separation.
In this paper, we will focus on label free CTCs isolation methods, in which the biophysical and biomechanical properties of cells (e.g., size, deformability, and electricity) are exploited for CTCs detection.
To assess the present state of various isolation methods, key performance metrics such as capture efficiency, cell viability, and throughput will be reported.
Finally, we discuss the challenges and future perspectives of CTC isolation technologies.
American Psychological Association (APA)
Low, Wan Shi& Wan Abas, Wan Abu Bakar. 2015. Benchtop Technologies for Circulating Tumor Cells Separation Based on Biophysical Properties. BioMed Research International،Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1054706
Modern Language Association (MLA)
Low, Wan Shi& Wan Abas, Wan Abu Bakar. Benchtop Technologies for Circulating Tumor Cells Separation Based on Biophysical Properties. BioMed Research International No. 2015 (2015), pp.1-22.
https://search.emarefa.net/detail/BIM-1054706
American Medical Association (AMA)
Low, Wan Shi& Wan Abas, Wan Abu Bakar. Benchtop Technologies for Circulating Tumor Cells Separation Based on Biophysical Properties. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-22.
https://search.emarefa.net/detail/BIM-1054706
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054706