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Artemisia princeps Inhibits Biofilm Formation and Virulence-Factor Expression of Antibiotic-Resistant Bacteria
Joint Authors
Kim, Kang-Ju
Kang, Sun-Young
Choi, Na-Young
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In this study, we used ethanol extract of A.
princeps and investigated its antibacterial effects against MRSA.
Ethanol extract of A.
princeps significantly inhibited MRSA growth and organic acid production during glucose metabolism at concentrations greater than 1 mg/mL (P < 0.05).
MRSA biofilm formation was observed using scanning electron microscopy (SEM) and safranin staining.
A.
princeps extract was found to inhibit MRSA biofilm formation at concentrations higher than 2 mg/mL significantly (P < 0.05).
Bactericidal effects of the A.
princeps were observed using confocal laser microscopy, which showed that A.
princeps was bactericidal in a dose-dependent manner.
Using real-time PCR, expression of mecA, an antibiotic-resistance gene of MRSA, was observed, along with that of sea, agrA, and sarA.
A.
princeps significantly inhibited mecA, sea, agrA, and sarA, mRNA expression at the concentrations greater than 1 mg/mL (P < 0.05).
The phytochemical analysis of A.
princeps showed a relatively high content of organic acids and glycosides.
The results of this study suggest that the ethanol extract of A.
princeps may inhibit proliferation, acid production, biofilm formation, and virulence gene expressions of MRSA, which may be related to organic acids and glycosides, the major components in the extract.
American Psychological Association (APA)
Choi, Na-Young& Kang, Sun-Young& Kim, Kang-Ju. 2015. Artemisia princeps Inhibits Biofilm Formation and Virulence-Factor Expression of Antibiotic-Resistant Bacteria. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054707
Modern Language Association (MLA)
Choi, Na-Young…[et al.]. Artemisia princeps Inhibits Biofilm Formation and Virulence-Factor Expression of Antibiotic-Resistant Bacteria. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054707
American Medical Association (AMA)
Choi, Na-Young& Kang, Sun-Young& Kim, Kang-Ju. Artemisia princeps Inhibits Biofilm Formation and Virulence-Factor Expression of Antibiotic-Resistant Bacteria. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054707
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054707