Poorly Understood Aspects of Striated Muscle Contraction
Joint Authors
Rassier, Dilson
Tsiavaliaris, Georgios
Månsson, Alf
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-28, 28 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-16
Country of Publication
Egypt
No. of Pages
28
Main Subjects
Abstract EN
Muscle contraction results from cyclic interactions between the contractile proteins myosin and actin, driven by the turnover of adenosine triphosphate (ATP).
Despite intense studies, several molecular events in the contraction process are poorly understood, including the relationship between force-generation and phosphate-release in the ATP-turnover.
Different aspects of the force-generating transition are reflected in the changes in tension development by muscle cells, myofibrils and single molecules upon changes in temperature, altered phosphate concentration, or length perturbations.
It has been notoriously difficult to explain all these events within a given theoretical framework and to unequivocally correlate observed events with the atomic structures of the myosin motor.
Other incompletely understood issues include the role of the two heads of myosin II and structural changes in the actin filaments as well as the importance of the three-dimensional order.
We here review these issues in relation to controversies regarding basic physiological properties of striated muscle.
We also briefly consider actomyosin mutation effects in cardiac and skeletal muscle function and the possibility to treat these defects by drugs.
American Psychological Association (APA)
Månsson, Alf& Rassier, Dilson& Tsiavaliaris, Georgios. 2015. Poorly Understood Aspects of Striated Muscle Contraction. BioMed Research International،Vol. 2015, no. 2015, pp.1-28.
https://search.emarefa.net/detail/BIM-1054733
Modern Language Association (MLA)
Månsson, Alf…[et al.]. Poorly Understood Aspects of Striated Muscle Contraction. BioMed Research International No. 2015 (2015), pp.1-28.
https://search.emarefa.net/detail/BIM-1054733
American Medical Association (AMA)
Månsson, Alf& Rassier, Dilson& Tsiavaliaris, Georgios. Poorly Understood Aspects of Striated Muscle Contraction. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-28.
https://search.emarefa.net/detail/BIM-1054733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054733