Antiphospholipase A2 Receptor Autoantibodies: A Step Forward in the Management of Primary Membranous Nephropathy
Joint Authors
Baston, Catalin
Obrisca, Bogdan
Jurubita, Roxana
Andronesi, Andreea
Mircescu, Gabriel
Ismail, Gener
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Since the identification of PLA2R (M-type phospholipase A2 receptor) as the first human antigenic target in primary membranous nephropathy (MN), perpetual progress has been made in understanding the pathogenesis of this disease.
Accumulating clinical data support a pathogenic role for the anti-PLA2R antibodies (PLA2R ABs), but confirmation in an animal model is still lacking.
However, PLA2R ABs were related to disease activity and outcome, as well as to response therapy.
Accordingly, PLA2R ABs assay seems to be promising tool not only to diagnose MN but also to predict the course of the disease and could open the way to personalize therapy.
Nevertheless, validation of a universal assay with high precision and definition of cut-off levels, followed by larger studies with a prolonged follow-up period, are needed to confirm these prospects.
American Psychological Association (APA)
Obrisca, Bogdan& Ismail, Gener& Jurubita, Roxana& Baston, Catalin& Andronesi, Andreea& Mircescu, Gabriel. 2015. Antiphospholipase A2 Receptor Autoantibodies: A Step Forward in the Management of Primary Membranous Nephropathy. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054752
Modern Language Association (MLA)
Obrisca, Bogdan…[et al.]. Antiphospholipase A2 Receptor Autoantibodies: A Step Forward in the Management of Primary Membranous Nephropathy. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054752
American Medical Association (AMA)
Obrisca, Bogdan& Ismail, Gener& Jurubita, Roxana& Baston, Catalin& Andronesi, Andreea& Mircescu, Gabriel. Antiphospholipase A2 Receptor Autoantibodies: A Step Forward in the Management of Primary Membranous Nephropathy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054752