Roles of ER β and GPR30 in Proliferative Response of Human Bladder Cancer Cell to Estrogen
Joint Authors
Huang, Weiren
Chen, Yuanbin
Liu, Yuchen
Zhang, Qiaoxia
Yu, Zhou
Mou, Lisha
Wu, Hanwei
Zhao, Li
Long, Ting
Qin, Danian
Gui, Yaoting
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Bladder cancer belongs to one of the most common cancers and is a leading cause of deaths in our society.
Urothelial carcinoma of the bladder (UCB) is the main type of this cancer, and the estrogen receptors in UCB remain to be studied.
Our experiment aimed to investigate the possible biological effect of 17β-estradiol on human bladder-derived T24 carcinoma cells and to indicate its related mechanisms.
T24 cells were treated with various doses of 17β-estradiol, and cell proliferation was detected using MTT assays.
17β-estradiol promoted T24 cell proliferation independent of ERβ/GPR30-regulated EGFR-MAPK pathway, while it inhibited cell growth via GPR30.
Furthermore, the expression levels of downstream genes (c-FOS, BCL-2, and CYCLIN D1) were increased by 17β-estradiol and this effect was independently associated with activity of the EGFR-MAPK pathway.
The two estrogen receptors might be potential therapeutic targets for the treatment of bladder cancer.
American Psychological Association (APA)
Huang, Weiren& Chen, Yuanbin& Liu, Yuchen& Zhang, Qiaoxia& Yu, Zhou& Mou, Lisha…[et al.]. 2015. Roles of ER β and GPR30 in Proliferative Response of Human Bladder Cancer Cell to Estrogen. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054758
Modern Language Association (MLA)
Huang, Weiren…[et al.]. Roles of ER β and GPR30 in Proliferative Response of Human Bladder Cancer Cell to Estrogen. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054758
American Medical Association (AMA)
Huang, Weiren& Chen, Yuanbin& Liu, Yuchen& Zhang, Qiaoxia& Yu, Zhou& Mou, Lisha…[et al.]. Roles of ER β and GPR30 in Proliferative Response of Human Bladder Cancer Cell to Estrogen. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054758
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054758