Prognostic Value of MACC1 in Digestive System Neoplasms: A Systematic Review and Meta-Analysis
Joint Authors
Wu, Zhenzhen
Zhou, Rui
Su, Yuqi
Sun, Li
Liao, Yulin
Liao, Wangjun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Metastasis associated in colon cancer 1 (MACC1), a newly identified oncogene, has been associated with poor survival of cancer patients by multiple studies.
However, the prognostic value of MACC1 in digestive system neoplasms needs systematic evidence to verify.
Therefore, we aimed to provide further evidence on this topic by systematic review and meta-analysis.
Literature search was conducted in multiple databases and eligible studies analyzing survival data and MACC1 expression were included for meta-analysis.
Hazard ratio (HR) for clinical outcome was chosen as an effect measure of interest.
According to our inclusion criteria, 18 studies with a total of 2,948 patients were identified.
Pooled HRs indicated that high MACC1 expression significantly correlates with poorer OS in patients with digestive system neoplasms (HR = 1.94; 95% CI: 1.49–2.53) as well as poorer relapse-free survival (HR = 1.94, 95% CI: 1.33–2.82).
The results of subgroup studies categorized by methodology, anatomic structure, and cancer subtype for pooled OS were all consistent with the overall pooled HR for OS as well.
No publication bias was detected according to test of funnel plot asymmetry and Egger’s test.
In conclusion, high MACC1 expression may serve as a prognostic biomarker to guide individualized management in clinical practice for digestive system neoplasms.
American Psychological Association (APA)
Wu, Zhenzhen& Zhou, Rui& Su, Yuqi& Sun, Li& Liao, Yulin& Liao, Wangjun. 2015. Prognostic Value of MACC1 in Digestive System Neoplasms: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054759
Modern Language Association (MLA)
Wu, Zhenzhen…[et al.]. Prognostic Value of MACC1 in Digestive System Neoplasms: A Systematic Review and Meta-Analysis. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054759
American Medical Association (AMA)
Wu, Zhenzhen& Zhou, Rui& Su, Yuqi& Sun, Li& Liao, Yulin& Liao, Wangjun. Prognostic Value of MACC1 in Digestive System Neoplasms: A Systematic Review and Meta-Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054759