An Improved Method for Completely Uncertain Biological Network Alignment
Joint Authors
Shen, Bin
Zhao, Muwei
Zhong, Wei
He, Jieyue
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
With the continuous development of biological experiment technology, more and more data related to uncertain biological networks needs to be analyzed.
However, most of current alignment methods are designed for the deterministic biological network.
Only a few can solve the probabilistic network alignment problem.
However, these approaches only use the part of probabilistic data in the original networks allowing only one of the two networks to be probabilistic.
To overcome the weakness of current approaches, an improved method called completely probabilistic biological network comparison alignment (C_PBNA) is proposed in this paper.
This new method is designed for complete probabilistic biological network alignment based on probabilistic biological network alignment (PBNA) in order to take full advantage of the uncertain information of biological network.
The degree of consistency (agreement) indicates that C_PBNA can find the results neglected by PBNA algorithm.
Furthermore, the GO consistency (GOC) and global network alignment score (GNAS) have been selected as evaluation criteria, and all of them proved that C_PBNA can obtain more biologically significant results than those of PBNA algorithm.
American Psychological Association (APA)
Shen, Bin& Zhao, Muwei& Zhong, Wei& He, Jieyue. 2015. An Improved Method for Completely Uncertain Biological Network Alignment. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054761
Modern Language Association (MLA)
Shen, Bin…[et al.]. An Improved Method for Completely Uncertain Biological Network Alignment. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054761
American Medical Association (AMA)
Shen, Bin& Zhao, Muwei& Zhong, Wei& He, Jieyue. An Improved Method for Completely Uncertain Biological Network Alignment. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054761