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The Level of Circulating Endothelial Progenitor Cell Is Associated with Cerebral Vasoreactivity: A Pilot Study
Joint Authors
Chung, Chih-Ping
Huang, Po-Hsun
Chen, Jia-Shiong
Yang, Kuang-Yao
Chen, J.-W.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Endothelial progenitor cell is known to be able to repair injured vessels.
We assessed the hypothesis that endothelial progenitor cell also modulates cerebral endothelial function in healthy status.
We used transcranial color-coded sonography to measure middle cerebral arterial vasoreactivity to CO2 (breath-holding index) in healthy subjects and observed its relationship with the number of circulating CD34CD133+ cells.
To detect significant correlations between each characteristic and breath-holding index of middle cerebral artery, we used univariate and multivariate regression analyses.
22 young healthy subjects were included in the present study (6 men, 16 women; mean age: 28.45 ± 3.98 years, range: 22–34 years).
The mean breath-holding index and CD45lowCD34+CD133+ cells number were 0.95 ± 0.48% and 0.52 ± 0.26, respectively.
The level of CD34CD133+ cells was independently associated with middle cerebral artery’s vasoreactivity (r=0.439,P=0.04).
Our results suggest that endothelial progenitor cell also modulates healthy cerebral vessels’ endothelial function.
This ability of endothelial progenitor cell could be potentially applied therapeutically and for prevention in conditions with cerebral endothelial dysfunction and cerebral ischemia.
American Psychological Association (APA)
Chung, Chih-Ping& Huang, Po-Hsun& Chen, Jia-Shiong& Chen, J.-W.& Yang, Kuang-Yao. 2015. The Level of Circulating Endothelial Progenitor Cell Is Associated with Cerebral Vasoreactivity: A Pilot Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1054785
Modern Language Association (MLA)
Chung, Chih-Ping…[et al.]. The Level of Circulating Endothelial Progenitor Cell Is Associated with Cerebral Vasoreactivity: A Pilot Study. BioMed Research International No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1054785
American Medical Association (AMA)
Chung, Chih-Ping& Huang, Po-Hsun& Chen, Jia-Shiong& Chen, J.-W.& Yang, Kuang-Yao. The Level of Circulating Endothelial Progenitor Cell Is Associated with Cerebral Vasoreactivity: A Pilot Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1054785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054785