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Osteoprotegerin and TRAIL in Acute Onset of Atrial Fibrillation
Joint Authors
Rewiuk, Krzysztof
Grodzicki, Tomasz K.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
There is a growing amount of evidence that inflammatory processes are involved in the development of atrial fibrillation (AF) and its complications.
We decided to investigate the behavior of osteoprotegerin (OPG) and TNF-related apoptosis inducing ligand (TRAIL) in terms of acute onset of AF.
Methods and Results.
We included 60 patients with acute onset of AF, candidates for pharmacological cardioversion.
The presence of cardiovascular comorbidities was connected with higher concentration of OPG and lower level of TRAIL right from the first hours of AF paroxysm.
The initial TRAIL level correlated also positively with left ventricle ejection fraction and negatively with left atrium diameter.
We found subsequent increase of OPG in subgroups selected on the basis of CHA2DS2-VASc scoring.
Although basal concentrations of studied markers did not allow prediction of the restoration of sinus rhythm, we observed important increase of TRAIL concentration in subgroup with sinus rhythm maintenance (94.11 ± 29.46 versus 111.39 ± 30.23 pg/mL; p=0.002).
Conclusions.
OPG and TRAIL are associated with the underlying cardiovascular damage in AF, but their balance is modulated by the fact of sinus rhythm restoration.
Determining the suitability of OPG and TRAIL as predictive markers in AF requires further prospective studies.
American Psychological Association (APA)
Rewiuk, Krzysztof& Grodzicki, Tomasz K.. 2015. Osteoprotegerin and TRAIL in Acute Onset of Atrial Fibrillation. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054795
Modern Language Association (MLA)
Rewiuk, Krzysztof& Grodzicki, Tomasz K.. Osteoprotegerin and TRAIL in Acute Onset of Atrial Fibrillation. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054795
American Medical Association (AMA)
Rewiuk, Krzysztof& Grodzicki, Tomasz K.. Osteoprotegerin and TRAIL in Acute Onset of Atrial Fibrillation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054795