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Comparison and Efficacy of LigaSure and Rubber Band Ligature in Closing the Inflamed Cecal Stump in a Rat Model of Acute Appendicitis
Joint Authors
Yeh, Chun-Chieh
Jan, Chia-Ing
Huang, Po-Han
Su, Wen-Pang
Chen, Hui-Chen
Jeng, Long-Bin
Chen, Jiun-Rong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Safety of either LigaSure or rubber band in closing inflamed appendiceal stump in acute appendicitis has been less investigated.
In this study, cecal ligation followed by resecting inflamed cecum was performed to mimic appendectomy in a rat model of acute appendicitis.
Rats were sacrificed immediately (Group A) and 7 days (Group B) after cecal resection, respectively.
The cecal stumps were closed by silk ligature (S), 5 mm LigaSure (L), or rubber band (R).
Seven days after cecal resection, the LigaSure (BL) and silk subgroups (BS) had significantly less intra-abdominal adhesion and better laparotomy wound healing than rubber band subgroup (BR).
The initial bursting pressure at cecal stump was comparable among the three methods; along with tissue healing process, both BL and BS provided a higher bursting pressure than BR 7 days after appendectomy.
BL subgroup had more abundant hydroxyproline deposition than BS and BR subgroup.
Furthermore, serum TNF-α in BR group kept persistently increasing along with time after cecal resection.
Thus, the finding that LigaSure but not rubber band is safe in sealing off the inflamed cecal stump in rat model of acute appendicitis suggests the possibility of applying LigaSure for appendectomy via single port procedure or natural orifice transluminal endoscopic surgery (NOTES).
American Psychological Association (APA)
Yeh, Chun-Chieh& Jan, Chia-Ing& Chen, Jiun-Rong& Huang, Po-Han& Jeng, Long-Bin& Su, Wen-Pang…[et al.]. 2015. Comparison and Efficacy of LigaSure and Rubber Band Ligature in Closing the Inflamed Cecal Stump in a Rat Model of Acute Appendicitis. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054797
Modern Language Association (MLA)
Yeh, Chun-Chieh…[et al.]. Comparison and Efficacy of LigaSure and Rubber Band Ligature in Closing the Inflamed Cecal Stump in a Rat Model of Acute Appendicitis. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054797
American Medical Association (AMA)
Yeh, Chun-Chieh& Jan, Chia-Ing& Chen, Jiun-Rong& Huang, Po-Han& Jeng, Long-Bin& Su, Wen-Pang…[et al.]. Comparison and Efficacy of LigaSure and Rubber Band Ligature in Closing the Inflamed Cecal Stump in a Rat Model of Acute Appendicitis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054797
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054797