Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Immunosuppressive Microenvironment
Joint Authors
Guo, Qiujun
Li, Jie
Lin, Hongsheng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Traditional Chinese medicine (TCM) is an important complementary strategy for treating cancer in China.
The mechanism is related to regulating the internal environment and remodeling the tumor immunosuppressive microenvironment (TIM).
Herein we illustrate how TIM is reformed and its protumor activity on promoting tumor cell proliferation, angiogenesis and lymphangiogenesis, tumor invasion, and the oncogenicity of cancer stem cells.
Furthermore we summarize the effects and mechanism of TCM on regulating TIM via enhancing antitumor immune responses (e.g., regulating the expression of MHC molecules and Fas/FasL, attenuating cancerigenic ability of cancer stem cells) and remolding immunosuppressive cells (e.g., reversing immune phenotypes of T lymphocytes and tumor associated macrophages, promoting dendritic cells mature, restraining myeloid derived suppressor cells function, and regulating Th1/Th2 factors).
We also reveal the bidirectional and multitargeting functions of TCM on regulating TIM.
Hopefully, it provides new theoretical basis for TCM clinical practice in cancer treatment and prevention.
American Psychological Association (APA)
Guo, Qiujun& Li, Jie& Lin, Hongsheng. 2015. Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Immunosuppressive Microenvironment. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054801
Modern Language Association (MLA)
Guo, Qiujun…[et al.]. Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Immunosuppressive Microenvironment. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1054801
American Medical Association (AMA)
Guo, Qiujun& Li, Jie& Lin, Hongsheng. Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Immunosuppressive Microenvironment. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054801