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Animal Models of Peritoneal Dialysis: Thirty Years of Our Own Experience
Joint Authors
Lindholm, Bengt
Hoppe, Krzysztof
Baum, Ewa
Breborowicz, Andrzej
Pawlaczyk, Krzysztof
Schwermer, Krzysztof
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Experimental animal models improve our understanding of technical problems in peritoneal dialysis PD, and such studies contribute to solving crucial clinical problems.
We established an acute and chronic PD model in nonuremic and uremic rats.
We observed that kinetics of PD in rats change as the animals are aging, and this effect is due not only to an increasing peritoneal surface area, but also to changes in the permeability of the peritoneum.
Changes of the peritoneal permeability seen during chronic PD in rats are comparable to results obtained in humans treated with PD.
Effluent dialysate can be drained repeatedly to measure concentration of various bioactive molecules and to correlate the results with the peritoneal permeability.
Additionally we can study in in vitro conditions properties of the effluent dialysate on cultured peritoneal mesothelial cells or fibroblasts.
We can evaluate acute and chronic effect of various additives to the dialysis fluid on function and permeability of the peritoneum.
Results from such study are even more relevant to the clinical scenario when experiments are performed in uremic rats.
Our experimental animal PD model not only helps to understand the pathophysiology of PD but also can be used for testing biocompatibility of new PD fluids.
American Psychological Association (APA)
Pawlaczyk, Krzysztof& Baum, Ewa& Schwermer, Krzysztof& Hoppe, Krzysztof& Lindholm, Bengt& Breborowicz, Andrzej. 2015. Animal Models of Peritoneal Dialysis: Thirty Years of Our Own Experience. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054803
Modern Language Association (MLA)
Pawlaczyk, Krzysztof…[et al.]. Animal Models of Peritoneal Dialysis: Thirty Years of Our Own Experience. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054803
American Medical Association (AMA)
Pawlaczyk, Krzysztof& Baum, Ewa& Schwermer, Krzysztof& Hoppe, Krzysztof& Lindholm, Bengt& Breborowicz, Andrzej. Animal Models of Peritoneal Dialysis: Thirty Years of Our Own Experience. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054803