Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma
Joint Authors
Chu, Ming
Xu, Lan
Zhang, Ming-bo
Chu, Zheng-yun
Wang, Yue-dan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Baicalin (BA) is a flavonoid compound purified from Scutellaria baicalensis Georgi and has been shown to possess a potent inhibitory activity against viruses.
However, the role of BA in anti-influenza virus has not been extensively studied, and the immunological mechanism of BA in antiviral activity remains unknown.
Here, we observed that BA could protect mice from infection by influenza virus A/PR/8/34 (H1N1), associated with increasing IFN-γ production, but presented no effects in IFN-γ or IFN-γ receptor deficient mice.
Further study indicated that BA could inhibit A/PR/8/34 replication through IFN-γ in human PBMC.
Moreover, BA can directly induce IFN-γ production in human CD4+ and CD8+ T cells and NK cells, and activate JAK/STAT-1 signaling pathway.
Collectively, BA exhibited anti-influenza virus A (H1N1) activity in vitro and in vivo as a potent inducer of IFN-γ in major IFN-γ producing cells.
American Psychological Association (APA)
Chu, Ming& Xu, Lan& Zhang, Ming-bo& Chu, Zheng-yun& Wang, Yue-dan. 2015. Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054810
Modern Language Association (MLA)
Chu, Ming…[et al.]. Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054810
American Medical Association (AMA)
Chu, Ming& Xu, Lan& Zhang, Ming-bo& Chu, Zheng-yun& Wang, Yue-dan. Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054810