Ethnic-Specific Genetic Association of Variants in the Corticotropin-Releasing Hormone Receptor 1 Gene with Nicotine Dependence
Joint Authors
Tang, Xiujun
Zhan, Shumin
Yang, Liping
Cui, Wenyan
Ma, Jennie Z.
Payne, Thomas J.
Li, Ming D.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Twin and family studies indicate that smoking addiction is highly influenced by genetic factors.
Variants in the corticotropin-releasing hormone receptor 1 (CRHR1) gene have been associated with alcoholism and depression.
In this study, we tested five single nucleotide polymorphisms (SNPs) in CRHR1 for their association with ND, which was assessed by smoking quantity (SQ), the Heaviness of Smoking Index (HSI), and the Fagerström test for ND (FTND) in 2,037 subjects from 602 families of either European American (EA) or African American (AA) ancestry.
Association analysis of the five SNPs revealed a significant association of rs171440 with SQ in the AA sample and with SQ and FTND in the pooled AA and EA samples.
Haplotype-based association analysis indicated significant association of haplotypes C-C (56.9%) and T-C (38.9%), formed by SNPs rs171440 and rs1396862, with SQ in the AA sample, C-C-G (47.6%) with SQ, and T-C-G (42.3%), formed by SNPs rs171440, rs1396862, and rs878886, with SQ and FTND in the pooled AA and EA samples.
However, none of these associations remained significant after correction for multiple testing.
Together, our results provide suggestive evidence for the involvement of CRHR1 in ND, which warrants further investigation using larger independent samples.
American Psychological Association (APA)
Tang, Xiujun& Zhan, Shumin& Yang, Liping& Cui, Wenyan& Ma, Jennie Z.& Payne, Thomas J.…[et al.]. 2015. Ethnic-Specific Genetic Association of Variants in the Corticotropin-Releasing Hormone Receptor 1 Gene with Nicotine Dependence. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054811
Modern Language Association (MLA)
Tang, Xiujun…[et al.]. Ethnic-Specific Genetic Association of Variants in the Corticotropin-Releasing Hormone Receptor 1 Gene with Nicotine Dependence. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054811
American Medical Association (AMA)
Tang, Xiujun& Zhan, Shumin& Yang, Liping& Cui, Wenyan& Ma, Jennie Z.& Payne, Thomas J.…[et al.]. Ethnic-Specific Genetic Association of Variants in the Corticotropin-Releasing Hormone Receptor 1 Gene with Nicotine Dependence. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054811