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Phylogenetic Analysis of Hemagglutinin Genes of H9N2 Avian Influenza Viruses Isolated from Chickens in Shandong, China, between 1998 and 2013
Joint Authors
Zhao, Yuxin
Li, Song
Zhou, Yufa
Song, Wengang
Tang, Yujing
Pang, Quanhai
Miao, Zengmin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Since H9N2 avian influenza virus (AIV) was first isolated in Guangdong province of China, the virus has been circulating in chicken flocks in mainland China.
However, a systematic phylogenetic analysis of H9N2 AIV from chickens in Shandong of China has not been conducted.
Based on hemagglutinin (HA) gene sequences of H9N2 AIVs isolated from chickens in Shandong of China between 1998 and 2013, genetic evolution of 35 HA gene sequences was systematically analyzed in this study.
Our findings showed that the majority of H9N2 AIVs (21 out of 35) belonged to the lineage h9.4.2.5.
Most of isolates (33 out of 35) had a PSRSSR↓GLF motif in HA cleavage site.
Importantly, 29 out of these 35 isolates had an amino acid exchange (Q226L) in the receptor-binding site.
The substitution showed that H9N2 AIVs had the potential affinity to bind to human-like receptor.
The currently prevalent H9N2 AIVs in Shandong belonged to the lineage h9.4.2.5 which are different from the vaccine strain SS/94 clade h9.4.2.3.
Therefore, the long-term surveillance of H9N2 AIVs is of significance to combat the possible H9N2 AIV outbreaks.
American Psychological Association (APA)
Zhao, Yuxin& Li, Song& Zhou, Yufa& Song, Wengang& Tang, Yujing& Pang, Quanhai…[et al.]. 2015. Phylogenetic Analysis of Hemagglutinin Genes of H9N2 Avian Influenza Viruses Isolated from Chickens in Shandong, China, between 1998 and 2013. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054818
Modern Language Association (MLA)
Zhao, Yuxin…[et al.]. Phylogenetic Analysis of Hemagglutinin Genes of H9N2 Avian Influenza Viruses Isolated from Chickens in Shandong, China, between 1998 and 2013. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054818
American Medical Association (AMA)
Zhao, Yuxin& Li, Song& Zhou, Yufa& Song, Wengang& Tang, Yujing& Pang, Quanhai…[et al.]. Phylogenetic Analysis of Hemagglutinin Genes of H9N2 Avian Influenza Viruses Isolated from Chickens in Shandong, China, between 1998 and 2013. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054818