The Role of Mifepristone in Meningiomas Management: A Systematic Review of the Literature
Joint Authors
Cossu, Giulia
Levivier, Marc
Messerer, Mahmoud
Daniel, Roy Thomas
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objectives.
We performed a systematic literature review to analyze the clinical application and the safety of mifepristone, a prominent antiprogesterone agent, in meningioma patients.
Materials and Methods.
A systematic search was performed through Medline, Cochrane, and clinicaltrials.gov databases from 1960 to 2014.
Study Selection.
Studies were selected through a PICO approach.
Population was meningioma patients, meningioma cells cultures, and animal models.
Intervention was mifepristone administration.
Control was placebo administration or any other drug tested.
Outcomes were clinical and radiological responsiveness, safety profile, and cell growth inhibition.
Results.
A total of 7 preclinical and 6 clinical studies and one abstract were included.
Encouraging results were found in preclinical studies.
Concerning clinical studies, the response rate to mifepristone in terms of radiological regression and symptomatic improvement/stability in patients with inoperable meningioma was low.
In meningiomatosis, favorable preliminary results were recorded.
The safety profile was good.
Limitations were as follows.
The tumoral expression of progesterone receptors was not analyzed systematically in every study considered.
Conclusions.
No clear evidence exists to recommend mifepristone in inoperable meningiomas.
Preliminary encouraging results were found in diffuse meningiomatosis.
Mifepristone is a well-tolerated treatment.
Patients’ selection and hormonal profile analysis in meningiomas are fundamental for a better understanding of its benefit.
Multicenter placebo-controlled trials are required.
American Psychological Association (APA)
Cossu, Giulia& Levivier, Marc& Daniel, Roy Thomas& Messerer, Mahmoud. 2015. The Role of Mifepristone in Meningiomas Management: A Systematic Review of the Literature. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054820
Modern Language Association (MLA)
Cossu, Giulia…[et al.]. The Role of Mifepristone in Meningiomas Management: A Systematic Review of the Literature. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054820
American Medical Association (AMA)
Cossu, Giulia& Levivier, Marc& Daniel, Roy Thomas& Messerer, Mahmoud. The Role of Mifepristone in Meningiomas Management: A Systematic Review of the Literature. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054820