The Effect of Latent Toxoplasma gondii Infection on the Immune Response in HIV-Infected Patients
Joint Authors
Davidová, Alžběta
Kodym, Petr
Maly, Marek
Reinvartova, Gabriela
Jilich, David
Rozsypal, Hanus
Beran, Ondřej
Holub, Michal
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A relationship between latent toxoplasmosis and the immune system during HIV disease is poorly understood.
Therefore, the aim of this follow-up study was to characterize immunological parameters in HIV-infected patients with latent toxoplasmosis and noninfected individuals.
A total of 101 HIV-infected patients were enrolled in the study.
The patients were classified into two groups based on anti-Toxoplasma gondii antibodies: a group of 55 toxoplasma-positive persons (TP) and a group of 46 toxoplasma-negative persons (TN).
Absolute counts of several lymphocyte subsets decreased in the TP group, namely, T cells (p=0.007), B cells (p=0.002), NK cells (p=0.009), CD4 T cells (p=0.028), and CD8 T cells (p=0.004).
On the other hand, the percentage of CD8 T cells expressing CD38 and HLA-DR significantly increased during the follow-up in the TP group (p=0.003, p=0.042, resp.) as well as the intensity of CD38 and HLA-DR expression (MFI) on CD8 T cells (p=0.001, p=0.057, resp.).
In the TN group, analysis of the kinetics of immunological parameters revealed no significant changes over time.
In conclusion, the results suggest that latent T.
gondii infection modulates the immune response during HIV infection.
American Psychological Association (APA)
Beran, Ondřej& Kodym, Petr& Maly, Marek& Davidová, Alžběta& Reinvartova, Gabriela& Jilich, David…[et al.]. 2015. The Effect of Latent Toxoplasma gondii Infection on the Immune Response in HIV-Infected Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054830
Modern Language Association (MLA)
Beran, Ondřej…[et al.]. The Effect of Latent Toxoplasma gondii Infection on the Immune Response in HIV-Infected Patients. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054830
American Medical Association (AMA)
Beran, Ondřej& Kodym, Petr& Maly, Marek& Davidová, Alžběta& Reinvartova, Gabriela& Jilich, David…[et al.]. The Effect of Latent Toxoplasma gondii Infection on the Immune Response in HIV-Infected Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054830