Iron Dextran Increases Hepatic Oxidative Stress and Alters Expression of Genes Related to Lipid Metabolism Contributing to Hyperlipidaemia in Murine Model
Joint Authors
Silva, Marcelo Eustáquio
Pedrosa, Maria Lucia
Lima, Wanderson Geraldo
Silva, Maísa
Guerra, Joyce Ferreira da Costa
Sampaio, Ana Flávia Santos
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The objective of this study was to investigate the effects of iron dextran on lipid metabolism and to determine the involvement of oxidative stress.
Fischer rats were divided into two groups: the standard group (S), which was fed the AIN-93M diet, and the standard plus iron group (SI), which was fed the same diet but also received iron dextran injections.
Serum cholesterol and triacylglycerol levels were higher in the SI group than in the S group.
Iron dextran was associated with decreased mRNA levels of pparα, and its downstream gene cpt1a, which is involved in lipid oxidation.
Iron dextran also increased mRNA levels of apoB-100, MTP, and L-FABP indicating alterations in lipid secretion.
Carbonyl protein and TBARS were consistently higher in the liver of the iron-treated rats.
Moreover, a significant positive correlation was found between oxidative stress products, lfabp expression, and iron stores.
In addition, a negative correlation was found between pparα expression, TBARS, carbonyl protein, and iron stores.
In conclusion, our results suggest that the increase observed in the transport of lipids in the bloodstream and the decreased fatty acid oxidation in rats, which was promoted by iron dextran, might be attributed to increased oxidative stress.
American Psychological Association (APA)
Silva, Maísa& Guerra, Joyce Ferreira da Costa& Sampaio, Ana Flávia Santos& Lima, Wanderson Geraldo& Silva, Marcelo Eustáquio& Pedrosa, Maria Lucia. 2015. Iron Dextran Increases Hepatic Oxidative Stress and Alters Expression of Genes Related to Lipid Metabolism Contributing to Hyperlipidaemia in Murine Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054832
Modern Language Association (MLA)
Silva, Maísa…[et al.]. Iron Dextran Increases Hepatic Oxidative Stress and Alters Expression of Genes Related to Lipid Metabolism Contributing to Hyperlipidaemia in Murine Model. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054832
American Medical Association (AMA)
Silva, Maísa& Guerra, Joyce Ferreira da Costa& Sampaio, Ana Flávia Santos& Lima, Wanderson Geraldo& Silva, Marcelo Eustáquio& Pedrosa, Maria Lucia. Iron Dextran Increases Hepatic Oxidative Stress and Alters Expression of Genes Related to Lipid Metabolism Contributing to Hyperlipidaemia in Murine Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054832