Effectiveness of the First Dose of BCG against Tuberculosis among HIV-Infected, Predominantly Immunodeficient Children
Joint Authors
Ximenes, Ricardo A. A.
Albuquerque, Maria de Fátima P. M. de
Van-Dunem, Joaquim C. V. D.
Rodrigues, Laura C.
Alencar, Luiz Claudio Arraes
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The objective of this study was to estimate the protective effect of Bacille Calmette-Guérin (BCG) vaccine against tuberculosis among (predominantly immunodeficient) HIV-infected children in Angola.
A hospital-based case-control study was conducted with 230 cases, children coinfected with tuberculosis, and 672 controls, HIV-infected children from the same hospital, aged 18 months to 13 years.
The presence of a vaccination scar was taken as a proxy marker for BCG vaccination.
The crude effectiveness was 8% (95% CI: −26 to 32) and the adjusted effectiveness was 30% (95% CI: −75 to 72).
The present study suggests that BCG does not have a protective effect against tuberculosis among immunodeficient HIV-infected children.
Since BCG is no longer given to HIV-infected children, the study may not be replicated.
Accepting that these findings should be considered with caution, they are nonetheless likely to be the last estimate of BCG efficacy in a sufficiently powered study.
American Psychological Association (APA)
Van-Dunem, Joaquim C. V. D.& Rodrigues, Laura C.& Alencar, Luiz Claudio Arraes& Albuquerque, Maria de Fátima P. M. de& Ximenes, Ricardo A. A.. 2015. Effectiveness of the First Dose of BCG against Tuberculosis among HIV-Infected, Predominantly Immunodeficient Children. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054842
Modern Language Association (MLA)
Van-Dunem, Joaquim C. V. D.…[et al.]. Effectiveness of the First Dose of BCG against Tuberculosis among HIV-Infected, Predominantly Immunodeficient Children. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054842
American Medical Association (AMA)
Van-Dunem, Joaquim C. V. D.& Rodrigues, Laura C.& Alencar, Luiz Claudio Arraes& Albuquerque, Maria de Fátima P. M. de& Ximenes, Ricardo A. A.. Effectiveness of the First Dose of BCG against Tuberculosis among HIV-Infected, Predominantly Immunodeficient Children. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054842