Neural and Nonneural Contributions to Wrist Rigidity in Parkinson’s Disease: An Explorative Study Using the NeuroFlexor
Joint Authors
Zetterberg, H.
Frykberg, G. E.
Gäverth, J.
Lindberg, P. G.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The NeuroFlexor is a novel method incorporating a biomechanical model for the measurement of neural and nonneural contributions to resistance induced by passive stretch.
In this study, we used the NeuroFlexor method to explore components of passive movement resistance in the wrist and finger muscles in subjects with Parkinson’s disease (PD).
Methods.
A cross-sectional comparison was performed in twenty-five subjects with PD with clinically identified rigidity and 14 controls.
Neural (NC), elastic (EC), and viscous (VC) components of the resistance to passive extension of the wrist were calculated using the NeuroFlexor.
Measurements were repeated during a contralateral activation maneuver.
Results.
PD subjects showed greater total resistance ( P < 0.001 ) and NC ( P = 0.002 ) compared to controls.
EC and VC did not differ significantly between groups.
Contralateral activation maneuver resulted in increased NC in the PD group but this increase was due to increased resting tension.
Total resistance and NC correlated with clinical ratings of rigidity and with bradykinesia.
Conclusions.
The findings suggest that stretch induced reflex activity, but not nonneural resistance, is the major contributor to rigidity in wrist muscles in PD.
The NeuroFlexor is a potentially valuable clinical and research tool for quantification of rigidity.
American Psychological Association (APA)
Zetterberg, H.& Frykberg, G. E.& Gäverth, J.& Lindberg, P. G.. 2015. Neural and Nonneural Contributions to Wrist Rigidity in Parkinson’s Disease: An Explorative Study Using the NeuroFlexor. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054848
Modern Language Association (MLA)
Zetterberg, H.…[et al.]. Neural and Nonneural Contributions to Wrist Rigidity in Parkinson’s Disease: An Explorative Study Using the NeuroFlexor. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054848
American Medical Association (AMA)
Zetterberg, H.& Frykberg, G. E.& Gäverth, J.& Lindberg, P. G.. Neural and Nonneural Contributions to Wrist Rigidity in Parkinson’s Disease: An Explorative Study Using the NeuroFlexor. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054848