Biology of Heme in Mammalian Erythroid Cells and Related Disorders
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Heme is a prosthetic group comprising ferrous iron (Fe2+) and protoporphyrin IX and is an essential cofactor in various biological processes such as oxygen transport (hemoglobin) and storage (myoglobin) and electron transfer (respiratory cytochromes) in addition to its role as a structural component of hemoproteins.
Heme biosynthesis is induced during erythroid differentiation and is coordinated with the expression of genes involved in globin formation and iron acquisition/transport.
However, erythroid and nonerythroid cells exhibit distinct differences in the heme biosynthetic pathway regulation.
Defects of heme biosynthesis in developing erythroblasts can have profound medical implications, as represented by sideroblastic anemia.
This review will focus on the biology of heme in mammalian erythroid cells, including the heme biosynthetic pathway as well as the regulatory role of heme and human disorders that arise from defective heme synthesis.
American Psychological Association (APA)
Fujiwara, Tohru& Harigae, Hideo. 2015. Biology of Heme in Mammalian Erythroid Cells and Related Disorders. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054851
Modern Language Association (MLA)
Fujiwara, Tohru& Harigae, Hideo. Biology of Heme in Mammalian Erythroid Cells and Related Disorders. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054851
American Medical Association (AMA)
Fujiwara, Tohru& Harigae, Hideo. Biology of Heme in Mammalian Erythroid Cells and Related Disorders. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054851