Genetic Variations in ABCG2 Gene Predict Breast Carcinoma Susceptibility and Clinical Outcomes after Treatment with Anthracycline-Based Chemotherapy
Joint Authors
Wang, En-Hua
Wu, Huizhe
Liu, Yong
Kang, Hui
Xiao, Qinghuan
Yao, Weifan
Zhao, Haishan
Wei, Minjie
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The genetic variants of the ATP-binding cassette, subfamily G, member 2 (ABCG2) are known to be involved in developing cancer risk and interindividual differences in chemotherapeutic response.
The polymorphisms in ABCG2 gene were genotyped by using PCR-RFLP assays.
We found that ABCG2 G34A GA/AA genotype, C421A AA genotype, and haplotypes 34A-421C and 34G-421A were significantly associated with increased risk for developing breast carcinoma.
Furthermore, ABCG2 C421A AA homozygote had a significant enhanced therapeutic response in patients with neoadjuvant anthracycline-based chemotherapy.
Moreover, ABCG2 G34A AA genotype carriers displayed a longer OS in ER positive patients or PR positive patients after postoperative anthracycline-based chemotherapy.
These results suggested that the ABCG2 polymorphisms might be a candidate pharmacogenomic factor to assess susceptibility and prognosis for breast carcinoma patients.
American Psychological Association (APA)
Wu, Huizhe& Liu, Yong& Kang, Hui& Xiao, Qinghuan& Yao, Weifan& Zhao, Haishan…[et al.]. 2015. Genetic Variations in ABCG2 Gene Predict Breast Carcinoma Susceptibility and Clinical Outcomes after Treatment with Anthracycline-Based Chemotherapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054854
Modern Language Association (MLA)
Wu, Huizhe…[et al.]. Genetic Variations in ABCG2 Gene Predict Breast Carcinoma Susceptibility and Clinical Outcomes after Treatment with Anthracycline-Based Chemotherapy. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1054854
American Medical Association (AMA)
Wu, Huizhe& Liu, Yong& Kang, Hui& Xiao, Qinghuan& Yao, Weifan& Zhao, Haishan…[et al.]. Genetic Variations in ABCG2 Gene Predict Breast Carcinoma Susceptibility and Clinical Outcomes after Treatment with Anthracycline-Based Chemotherapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054854
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054854