Short Duration Combined Mild Hypothermia Improves Resuscitation Outcomes in a Porcine Model of Prolonged Cardiac Arrest
Joint Authors
Li, Yongqin
Yu, Tao
Li, Heng
Yang, Zhengfei
Ding, Youde
Huang, Zitong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
In this study, our aim was to investigate the effects of combined hypothermia with short duration maintenance on the resuscitation outcomes in a porcine model of ventricular fibrillation (VF).
Methods.
Fourteen porcine models were electrically induced with VF and untreated for 11 mins.
All animals were successfully resuscitated manually and then randomized into two groups: combined mild hypothermia (CH group) and normothermia group (NT group).
A combined hypothermia of ice cold saline infusion and surface cooling was implemented in the animals of the CH group and maintained for 4 hours.
The survival outcomes and neurological function were evaluated every 24 hours until a maximum of 96 hours.
Neuron apoptosis in hippocampus was analyzed.
Results.
There were no significant differences in baseline physiologies and primary resuscitation outcomes between both groups.
Obvious improvements of cardiac output were observed in the CH group at 120, 180, and 240 mins following resuscitation.
The animals demonstrated better survival at 96 hours in the CH group when compared to the NT group.
In comparison with the NT group, favorable neurological functions were observed in the CH group.
Conclusion.
Short duration combined cooling initiated after resuscitation improves survival and neurological outcomes in a porcine model of prolonged VF.
American Psychological Association (APA)
Yu, Tao& Yang, Zhengfei& Li, Heng& Ding, Youde& Huang, Zitong& Li, Yongqin. 2015. Short Duration Combined Mild Hypothermia Improves Resuscitation Outcomes in a Porcine Model of Prolonged Cardiac Arrest. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054855
Modern Language Association (MLA)
Yu, Tao…[et al.]. Short Duration Combined Mild Hypothermia Improves Resuscitation Outcomes in a Porcine Model of Prolonged Cardiac Arrest. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054855
American Medical Association (AMA)
Yu, Tao& Yang, Zhengfei& Li, Heng& Ding, Youde& Huang, Zitong& Li, Yongqin. Short Duration Combined Mild Hypothermia Improves Resuscitation Outcomes in a Porcine Model of Prolonged Cardiac Arrest. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054855