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The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese
Joint Authors
Chang, Hsueh-Wei
Chuang, Li-Yeh
Ou-Yang, Fu
Hou, Ming-Feng
Lin, Yu-Da
Yang, Cheng-Hong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The ORAI calcium release-activated calcium modulator 1 (ORAI1) has been proven to be an important gene for breast cancer progression and metastasis.
However, the protective association model between the single nucleotide polymorphisms (SNPs) of ORAI1 gene was not investigated.
Based on a published data set of 345 female breast cancer patients and 290 female controls, we used a particle swarm optimization (PSO) algorithm to identify the possible protective models of breast cancer association in terms of the SNPs of ORAI1 gene.
Results showed that the PSO-generated models of 2-SNP (rs12320939-TT/rs12313273-CC), 3-SNP (rs12320939-TT/rs12313273-CC/rs712853-(TT/TC)), 4-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs712853-(TT/TC)), and 5-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs6486795-CC/rs712853-(TT/TC)) displayed low values of odds ratios (0.409–0.425) for breast cancer association.
Taken together, these results suggested that our proposed PSO strategy is powerful to identify the combinational SNPs of rs12320939, rs12313273, rs7135617, rs6486795, and rs712853 of ORAI1 gene with a strongly protective association in breast cancer.
American Psychological Association (APA)
Ou-Yang, Fu& Lin, Yu-Da& Chuang, Li-Yeh& Chang, Hsueh-Wei& Yang, Cheng-Hong& Hou, Ming-Feng. 2015. The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054865
Modern Language Association (MLA)
Ou-Yang, Fu…[et al.]. The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054865
American Medical Association (AMA)
Ou-Yang, Fu& Lin, Yu-Da& Chuang, Li-Yeh& Chang, Hsueh-Wei& Yang, Cheng-Hong& Hou, Ming-Feng. The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054865