BMP-2 Grafted nHAPLGA Hybrid Nanofiber Scaffold Stimulates Osteoblastic Cells Growth

Joint Authors

Haider, Adnan
Huh, Man-Woo
Kang, Inn-Kyu
Kim, Sukyoung

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-10-11

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Medicine

Abstract EN

Biomaterials play a pivotal role in regenerative medicine, which aims to regenerate and replace lost/degenerated tissues or organs.

Natural bone is a hierarchical structure, comprised of various cells having specific functions that are regulated by sophisticated mechanisms.

However, the regulation of the normal functions in damaged or injured cells is disrupted.

In order to address this problem, we attempted to artificially generate a scaffold for mimicking the characteristics of the extracellular matrix at the nanoscale level to trigger osteoblastic cell growth.

For this purpose, we have chemically grafted bone morphogenetic protein (BMP-2) onto the surface of L-glutamic acid modified hydroxyapatite incorporated into the PLGA nanofiber matrix.

After extensive characterization using various spectroscopic techniques, the BMP-g-nHA/PLGA hybrid nanofiber scaffolds were subjected to various in vitro cytocompatibility tests.

The results indicated that BMP-2 on BMP-g-nHA/PLGA hybrid nanofiber scaffolds greatly stimulated osteoblastic cells growth, contrary to the nHA/PLGA and pristine PLGA nanofiber scaffold, which are used as control.

These results suggest that BMP-g-nHA/PLGA hybrid nanofiber scaffold can be used as a nanodrug carrier for the controlled and targeted delivery of BMP-2, which will open new possibilities for enhancing bone tissue regeneration and will help in the treatment of various bone-related diseases in the future.

American Psychological Association (APA)

Haider, Adnan& Kim, Sukyoung& Huh, Man-Woo& Kang, Inn-Kyu. 2015. BMP-2 Grafted nHAPLGA Hybrid Nanofiber Scaffold Stimulates Osteoblastic Cells Growth. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054869

Modern Language Association (MLA)

Haider, Adnan…[et al.]. BMP-2 Grafted nHAPLGA Hybrid Nanofiber Scaffold Stimulates Osteoblastic Cells Growth. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1054869

American Medical Association (AMA)

Haider, Adnan& Kim, Sukyoung& Huh, Man-Woo& Kang, Inn-Kyu. BMP-2 Grafted nHAPLGA Hybrid Nanofiber Scaffold Stimulates Osteoblastic Cells Growth. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054869

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1054869