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HPV Testing from Dried Urine Spots as a Tool for Cervical Cancer Screening in Low-Income Countries
Joint Authors
Frati, Elena Rosanna
Fasoli, Ester
Colzani, Daniela
Bianchi, Silvia
Binda, Sandro
Olivani, Pierfranco
Tanzi, Elisabetta
Martinelli, Marianna
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Nowadays, several screening strategies are available to prevent cervical cancer, but inadequate resources, sociocultural barriers, and sampling issues impede their success in low-income countries.
To overcome these issues, this study aimed to evaluate the performance of human papillomavirus (HPV) testing from dried urine spots (DUS).
Eighty-eight urine samples (including 56 HPV DNA positive specimens) were spotted on filter paper, dried, and stored in paper-bags.
HPV DNA was detected from the DUS after 1 week and 4 weeks of storage using a polymerase chain reaction (PCR) assay.
The sensitivity, specificity, and concordance of the DUS-based HPV test were evaluated by comparing the results with those of HPV testing on fresh urine samples as the gold standard.
The sensitivity of the test was 98.21% (95% CI: 90.56–99.68) for DUS stored for 1 week and 96.42% (95% CI: 87.88–99.01) for DUS stored for 4 weeks.
The specificity was 100% (95% CI: 89.28–100) at both time points.
The concordance between DUS and fresh urine HPV testing was “almost perfect” using the κ statistic.
These preliminary data suggest that a DUS-based assay could bypass sociocultural barriers and sampling issues and therefore could be a suitable, effective tool for epidemiological surveillance and screening programs, especially in low-income countries.
American Psychological Association (APA)
Frati, Elena Rosanna& Martinelli, Marianna& Fasoli, Ester& Colzani, Daniela& Bianchi, Silvia& Binda, Sandro…[et al.]. 2015. HPV Testing from Dried Urine Spots as a Tool for Cervical Cancer Screening in Low-Income Countries. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1054875
Modern Language Association (MLA)
Frati, Elena Rosanna…[et al.]. HPV Testing from Dried Urine Spots as a Tool for Cervical Cancer Screening in Low-Income Countries. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1054875
American Medical Association (AMA)
Frati, Elena Rosanna& Martinelli, Marianna& Fasoli, Ester& Colzani, Daniela& Bianchi, Silvia& Binda, Sandro…[et al.]. HPV Testing from Dried Urine Spots as a Tool for Cervical Cancer Screening in Low-Income Countries. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1054875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054875