Cardioprotective Effects of Tualang Honey: Amelioration of Cholesterol and Cardiac Enzymes Levels
Joint Authors
Sulaiman, Siti Amrah
Afroz, Rizwana
Tanvir, E. M.
Khalil, Md. Ibrahim
Gan, Siew Hua
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study was designed to investigate the cardioprotective effects of Malaysian Tualang honey against isoproterenol- (ISO-) induced myocardial infarction (MI) in rats by investigating changes in the levels of cardiac marker enzymes, cardiac troponin I (cTnI), triglycerides (TG), total cholesterol (TC), lipid peroxidation (LPO) products, and antioxidant defense system combined with histopathological examination.
Male albino Wistar rats (n = 40) were pretreated orally with Tualang honey (3 g/kg/day) for 45 days.
Subcutaneous injection of ISO (85 mg/kg in saline) for two consecutive days caused a significant increase in serum cardiac marker enzymes (creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and aspartate transaminase (AST)), cTnI, serum TC, and TG levels.
In addition, ISO-induced myocardial injury was confirmed by a significant increase in heart lipid peroxidation (LPO) products (TBARS) and a significant decrease in antioxidant enzymes (SOD, GPx, GRx, and GST).
Pretreatment of ischemic rats with Tualang honey conferred significant protective effects on all of the investigated biochemical parameters.
The biochemical findings were further confirmed by histopathological examination in both Tualang-honey-pretreated and ISO-treated hearts.
The present study demonstrates that Tualang honey confers cardioprotective effects on ISO-induced oxidative stress by contributing to endogenous antioxidant enzyme activity via inhibition of lipid peroxidation.
American Psychological Association (APA)
Khalil, Md. Ibrahim& Tanvir, E. M.& Afroz, Rizwana& Sulaiman, Siti Amrah& Gan, Siew Hua. 2015. Cardioprotective Effects of Tualang Honey: Amelioration of Cholesterol and Cardiac Enzymes Levels. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054896
Modern Language Association (MLA)
Khalil, Md. Ibrahim…[et al.]. Cardioprotective Effects of Tualang Honey: Amelioration of Cholesterol and Cardiac Enzymes Levels. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054896
American Medical Association (AMA)
Khalil, Md. Ibrahim& Tanvir, E. M.& Afroz, Rizwana& Sulaiman, Siti Amrah& Gan, Siew Hua. Cardioprotective Effects of Tualang Honey: Amelioration of Cholesterol and Cardiac Enzymes Levels. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054896