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Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype
Joint Authors
Alchera, Elisa
Imarisio, Chiara
Mandili, Giorgia
Merlin, Simone
Chandrashekar, Bangalore R.
Novelli, Francesco
Follenzi, Antonia
Carini, Rita
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ischemic preconditioning (IP) of the liver by a brief interruption of the blood flow protects the damage induced by a subsequent ischemia/reperfusion (I/R) preventing parenchymal and nonparenchymal liver cell damage.
The discovery of IP has shown the existence of intrinsic systems of cytoprotection whose activation can stave off the progression of irreversible tissue damage.
Deciphering the molecular mediators that underlie the cytoprotective effects of preconditioning can pave the way to important therapeutic possibilities.
Pharmacological activation of critical mediators of IP would be expected to emulate or even to intensify its salubrious effects.
In vitro and in vivo studies have demonstrated the role of the adenosine A2a receptor (A2aR) as a trigger of liver IP.
This review will provide insight into the phenotypic changes that underline the resistance to death of liver cells preconditioned by pharmacological activation of A2aR and their implications to develop innovative strategies against liver IR damage.
American Psychological Association (APA)
Alchera, Elisa& Imarisio, Chiara& Mandili, Giorgia& Merlin, Simone& Chandrashekar, Bangalore R.& Novelli, Francesco…[et al.]. 2015. Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054899
Modern Language Association (MLA)
Alchera, Elisa…[et al.]. Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054899
American Medical Association (AMA)
Alchera, Elisa& Imarisio, Chiara& Mandili, Giorgia& Merlin, Simone& Chandrashekar, Bangalore R.& Novelli, Francesco…[et al.]. Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054899