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The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease
Joint Authors
Feldman, Alexandra
Aigner, Elmar
Paulmichl, Katharina
Weghuber, Daniel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Obesity is a rapidly growing health problem and is paralleled by a multitude of comorbidities, including nonalcoholic fatty liver disease (NAFLD).
NAFLD has become the most common chronic liver disease in both adults and children.
The current understanding of NAFLD is still fragmentary.
While simple steatosis is characterized by the interplay between excessive free fatty acid accumulation and hepatic insulin resistance, the progression to NASH has been related to oxidative stress and a proinflammatory state with dysbalanced adipokine, cytokine levels, and endotoxin-mediated immune response.
In addition, oxidative stress has been suggested to play a central role for the sequelae leading to NASH.
Trace elements are critical in regulatory, immunologic, and antioxidant functions resulting in protection against inflammation and peroxidation and consequently against the known comorbidities of obesity.
Disruptions of the metal detoxification processes located in the liver are plausibly related to NAFLD development via oxidative stress.
Perturbations of iron and copper (Cu) homeostasis have been shown to contribute to the pathogenesis of NAFLD.
This review presents current data from pediatric studies.
In addition, data from adult studies are summarized where clinical relevance may be extrapolated to pediatric obesity and NAFLD.
American Psychological Association (APA)
Feldman, Alexandra& Aigner, Elmar& Weghuber, Daniel& Paulmichl, Katharina. 2015. The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054904
Modern Language Association (MLA)
Feldman, Alexandra…[et al.]. The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054904
American Medical Association (AMA)
Feldman, Alexandra& Aigner, Elmar& Weghuber, Daniel& Paulmichl, Katharina. The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054904