The HDAC Inhibitor Vorinostat Diminishes the In Vitro Metastatic Behavior of Osteosarcoma Cells
Joint Authors
Weiss, Kurt R.
Brynien, Daniel
Mu, Xiaodong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Osteosarcoma (OS) is the most common primary malignancy of bone and affects patients in the first two decades of life.
The greatest determinant of survival is the presence of pulmonary metastatic disease.
The role of epigenetic regulation in OS, specifically the biology of metastases, is unknown.
Our previous study with the murine OS cell populations K7M2 and K12 demonstrated a significant correlation of metastatic potential with the DNA methylation level of tumor suppressor genes.
In the current study, we investigated if the histone deacetylase (HDAC) inhibitor, vorinostat, could regulate the metastatic potential of highly metastatic OS cells.
Our results revealed that vorinostat treatment of highly metastatic K7M2 OS cells was able to greatly reduce the proliferation and metastatic potential of the cells.
Morphological features related to cell motility and invasion were changed by vorinostat treatment.
In addition, the gene expressions of mTOR, ALDH1, and PGC-1 were downregulated by vorinostat treatment.
These data suggest that vorinostat may be an effective modulator of OS cell metastatic potential and should be studied in preclinical models of metastatic OS.
American Psychological Association (APA)
Mu, Xiaodong& Brynien, Daniel& Weiss, Kurt R.. 2015. The HDAC Inhibitor Vorinostat Diminishes the In Vitro Metastatic Behavior of Osteosarcoma Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054911
Modern Language Association (MLA)
Mu, Xiaodong…[et al.]. The HDAC Inhibitor Vorinostat Diminishes the In Vitro Metastatic Behavior of Osteosarcoma Cells. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054911
American Medical Association (AMA)
Mu, Xiaodong& Brynien, Daniel& Weiss, Kurt R.. The HDAC Inhibitor Vorinostat Diminishes the In Vitro Metastatic Behavior of Osteosarcoma Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054911