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Impact of Infection Dose and Previous Serum Antibodies against the Locus of Enterocyte Effacement Proteins on Escherichia coli O157:H7 Shedding in Calves following Experimental Infection
Joint Authors
Cataldi, Angel Adrián
Martorelli, L.
Vilte, D. A.
Albanese, A.
Cantet, R. J. C.
Mercado, E. C.
Hovde, Carolyn J.
Zotta, Elsa
Ibarra, Cristina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Escherichia coli O157:H7 is the main causative agent of haemolytic uremic syndrome.
Cattle are the main reservoir of these bacteria, and have been shown to develop immune response to colonization.
Our aim was to investigate the faecal shedding pattern of E.
coli O157:H7 in calves challenged intragastrically with either 108 or 1010 CFU, as well as the ability of specific preexisting antibodies to reduce shedding of the pathogen.
Shedding was analysed by direct counting as well as enrichment of rectoanal mucosal swabs.
Statistical analysis was performed using a linear model for repeated measures with and without the inclusion of preexisting antibodies against the carboxy-terminal fraction of intimin-γ (γ-intimin C280) as a covariable.
Results suggest that there is a statistical difference in the area under the shedding curves between both doses for 14 as well as 28 days after challenge (p = 0.0069 and 0.0209, resp.).
This difference is increased when the prechallenge antibodies are taken into account (p = 0.0056 and 0.0185).
We concluded that the bacterial dose influences shedding on calves experimentally challenged and that preexisting antibodies against E.
coli O157:H7 γ-intimin C280 could partially reduce faecal excretion.
American Psychological Association (APA)
Martorelli, L.& Hovde, Carolyn J.& Vilte, D. A.& Albanese, A.& Zotta, Elsa& Ibarra, Cristina…[et al.]. 2015. Impact of Infection Dose and Previous Serum Antibodies against the Locus of Enterocyte Effacement Proteins on Escherichia coli O157:H7 Shedding in Calves following Experimental Infection. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054913
Modern Language Association (MLA)
Martorelli, L.…[et al.]. Impact of Infection Dose and Previous Serum Antibodies against the Locus of Enterocyte Effacement Proteins on Escherichia coli O157:H7 Shedding in Calves following Experimental Infection. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054913
American Medical Association (AMA)
Martorelli, L.& Hovde, Carolyn J.& Vilte, D. A.& Albanese, A.& Zotta, Elsa& Ibarra, Cristina…[et al.]. Impact of Infection Dose and Previous Serum Antibodies against the Locus of Enterocyte Effacement Proteins on Escherichia coli O157:H7 Shedding in Calves following Experimental Infection. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054913