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Transdermal Nicotine Application Attenuates Cardiac Dysfunction after Severe Thermal Injury
Joint Authors
Papst, Stephan
Steinstraesser, Lars
Kraft, Theresia
Niederbichler, Andreas D.
Stukenborg-Colsman, Christina
Reimers, Kerstin
Vogt, Peter M.
Claassen, Leif
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Severe burn trauma leads to an immediate and strong inflammatory response inciting cardiac dysfunction that is associated with high morbidity and mortality.
The aim of this study was to determine whether transdermal application of nicotine could influence the burn-induced cardiac dysfunction via its known immunomodulatory effects.
Material and Methods.
A standardized rat burn model was used in 35 male Sprague Dawley rats.
The experimental animals were divided into a control group, a burn trauma group, a burn trauma group with additional nicotine treatment, and a sham group with five experimental animals per group.
The latter two groups received nicotine administration.
Using microtip catheterization, functional parameters of the heart were assessed 12 or 24 hours after infliction of burn trauma.
Results.
Burn trauma led to significantly decreased blood pressure (BP) values whereas nicotine administration normalized BP.
As expected, burn trauma also induced a significant deterioration of myocardial contractility and relaxation parameters.
After application of nicotine these adverse effects were attenuated.
Conclusion.
The present study showed that transdermal nicotine administration has normalizing effects on burn-induced myocardial dysfunction parameters.
Further research is warranted to gain insight in molecular mechanisms and pathways and to evaluate potential treatment options in humans.
American Psychological Association (APA)
Claassen, Leif& Papst, Stephan& Reimers, Kerstin& Stukenborg-Colsman, Christina& Steinstraesser, Lars& Vogt, Peter M.…[et al.]. 2015. Transdermal Nicotine Application Attenuates Cardiac Dysfunction after Severe Thermal Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054921
Modern Language Association (MLA)
Claassen, Leif…[et al.]. Transdermal Nicotine Application Attenuates Cardiac Dysfunction after Severe Thermal Injury. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054921
American Medical Association (AMA)
Claassen, Leif& Papst, Stephan& Reimers, Kerstin& Stukenborg-Colsman, Christina& Steinstraesser, Lars& Vogt, Peter M.…[et al.]. Transdermal Nicotine Application Attenuates Cardiac Dysfunction after Severe Thermal Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054921