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The Quantified Level of Circulating Prostate Stem Cell Antigen mRNA relative to GAPDH Level Is a Clinically Significant Indictor for Predicting Biochemical Recurrence in Prostate Cancer Patients after Radical Prostatectomy
Joint Authors
Lee, Sang-Jin
Joung, Jae Young
Park, Weon Seo
Chung, Jinsoo
Lee, Kang Hyun
Kim, Sung Han
Choi, Moon Kyung
Yeon, Seung Min
Joo, Jeong Nam
Ko, Ara
Lee, Eun Sik
Seo, Ho Kyung
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The study quantified the relative absolute PSCA level in relation to the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) level in the peripheral blood of 478 hormone-naive prostate cancer (PC) patients who underwent radical prostatectomy from 2005 to 2012 and evaluated its prognostic significance as a risk factor for predicting biochemical recurrence (BCR), compared to known parameters.
Nested real-time polymerase chain reaction (RT-PCR) and gel electrophoresis detected PSCA levels and measured the PSCA/GAPDH ratio.
Clinicopathological data from the institutional database were examined to determine the adequate cut-off level to predict postoperative BCR.
A total of 110 patients had a positive PSCA result (23.0%) via RT-PCR (mean blood ratio 1.1 ± 0.4).
The BCR was significantly higher in the PSCA-positive detection group (p=0.009).
A multivariate model was created to show that a PSCA/GAPDH ratio between 1.0 and 1.5 (HR 12.722), clinical T2c stage (HR 0.104), preoperative PSA (HR 1.225), extraprostatic capsule extension (HR 0.006), lymph node dissection (HR 16.437), and positive resection margin (HR 27.453) were significant predictive factors for BCR (p<0.05).
The study showed successful quantification of PSCA with its significance for BCR-related risk factor; however, further studies are needed to confirm its clinical predictive value.
American Psychological Association (APA)
Kim, Sung Han& Park, Weon Seo& Lee, Sang-Jin& Choi, Moon Kyung& Yeon, Seung Min& Joo, Jeong Nam…[et al.]. 2015. The Quantified Level of Circulating Prostate Stem Cell Antigen mRNA relative to GAPDH Level Is a Clinically Significant Indictor for Predicting Biochemical Recurrence in Prostate Cancer Patients after Radical Prostatectomy. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054924
Modern Language Association (MLA)
Kim, Sung Han…[et al.]. The Quantified Level of Circulating Prostate Stem Cell Antigen mRNA relative to GAPDH Level Is a Clinically Significant Indictor for Predicting Biochemical Recurrence in Prostate Cancer Patients after Radical Prostatectomy. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054924
American Medical Association (AMA)
Kim, Sung Han& Park, Weon Seo& Lee, Sang-Jin& Choi, Moon Kyung& Yeon, Seung Min& Joo, Jeong Nam…[et al.]. The Quantified Level of Circulating Prostate Stem Cell Antigen mRNA relative to GAPDH Level Is a Clinically Significant Indictor for Predicting Biochemical Recurrence in Prostate Cancer Patients after Radical Prostatectomy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054924