In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin
Joint Authors
Douglas Melo Coutinho, Henrique
Fachinetto, Roselei
Braga, Maria F. B. M.
Boligon, Aline Augusti
Linde Athayde, Margareth
de Oliveira, Dayanne R.
Tintino, Saulo R.
de Menezes, Irwin Rose Alencar
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianum L.
Gaertn.) clinically used as an antihepatotoxic agent.
The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice.
Silymarin demonstrated antimicrobial activity of little significance against the bacterial strains tested, with MIC (minimum inhibitory concentration) values of 512 µg/mL.
Meanwhile, silibinin showed significant activity against Escherichia coli with a MIC of 64 µg/mL.
The results for the antifungal activity of silymarin and silibinin demonstrated a MIC of 1024 µg/mL for all strains.
Silymarin and silibinin appear to have promising potential, showing synergistic properties when combined with antibacterial drugs, which should prompt further studies along this line.
American Psychological Association (APA)
de Oliveira, Dayanne R.& Tintino, Saulo R.& Braga, Maria F. B. M.& Boligon, Aline Augusti& Linde Athayde, Margareth& Douglas Melo Coutinho, Henrique…[et al.]. 2015. In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054929
Modern Language Association (MLA)
de Oliveira, Dayanne R.…[et al.]. In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054929
American Medical Association (AMA)
de Oliveira, Dayanne R.& Tintino, Saulo R.& Braga, Maria F. B. M.& Boligon, Aline Augusti& Linde Athayde, Margareth& Douglas Melo Coutinho, Henrique…[et al.]. In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054929