Oxidative Stress in Placenta: Health and Diseases
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
During pregnancy, development of the placenta is interrelated with the oxygen concentration.
Embryo development takes place in a low oxygen environment until the beginning of the second trimester when large amounts of oxygen are conveyed to meet the growth requirements.
High metabolism and oxidative stress are common in the placenta.
Reactive oxidative species sometimes harm placental development, but they are also reported to regulate gene transcription and downstream activities such as trophoblast proliferation, invasion, and angiogenesis.
Autophagy and apoptosis are two crucial, interconnected processes in the placenta that are often influenced by oxidative stress.
The proper interactions between them play an important role in placental homeostasis.
However, an imbalance between the protective and destructive mechanisms of autophagy and apoptosis seems to be linked with pregnancy-related disorders such as miscarriage, preeclampsia, and intrauterine growth restriction.
Thus, potential therapies to hold oxidative stress in leash, promote placentation, and avoid unwanted apoptosis are discussed.
American Psychological Association (APA)
Wu, Fan& Tian, Fu-Ju& Lin, Yi. 2015. Oxidative Stress in Placenta: Health and Diseases. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1054932
Modern Language Association (MLA)
Wu, Fan…[et al.]. Oxidative Stress in Placenta: Health and Diseases. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1054932
American Medical Association (AMA)
Wu, Fan& Tian, Fu-Ju& Lin, Yi. Oxidative Stress in Placenta: Health and Diseases. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1054932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054932