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Regenerating Salivary Glands in the Microenvironment of Induced Pluripotent Stem Cells
Joint Authors
Ono, Hitomi
Obana, Aya
Usami, Yu
Sakai, Manabu
Nohara, Kanji
Egusa, Hiroshi
Sakai, Takayoshi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This report describes our initial attempt to regenerate salivary glands using induced pluripotent stem (iPS) cells in vivo and in vitro.
Glandular tissues that were similar to the adult submandibular glands (SMGs) and sublingual glands could be partially produced by the transplantation of iPS cells into mouse salivary glands.
However, the tumorigenicity of iPS cells has not been resolved yet.
It is well known that stem cells affect their microenvironment, known as a stem cell niche.
We focused on the niche and the interaction between iPS cells and salivary gland cells in our study on salivary gland regeneration.
Coculture of embryonic SMG cells and iPS cells have better-developed epithelial structures and fewer undifferentiated specific markers than monoculture of embryonic SMG cells in vitro.
These results suggest that iPS cells have a potential ability to accelerate differentiation for salivary gland development and regeneration.
American Psychological Association (APA)
Ono, Hitomi& Obana, Aya& Usami, Yu& Sakai, Manabu& Nohara, Kanji& Egusa, Hiroshi…[et al.]. 2015. Regenerating Salivary Glands in the Microenvironment of Induced Pluripotent Stem Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054936
Modern Language Association (MLA)
Ono, Hitomi…[et al.]. Regenerating Salivary Glands in the Microenvironment of Induced Pluripotent Stem Cells. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054936
American Medical Association (AMA)
Ono, Hitomi& Obana, Aya& Usami, Yu& Sakai, Manabu& Nohara, Kanji& Egusa, Hiroshi…[et al.]. Regenerating Salivary Glands in the Microenvironment of Induced Pluripotent Stem Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054936